过氧化物酶体生物发生及相关疾病研究进展  

Research Progress of Peroxisome Biogenesis and Related Diseases

作　　者：郑建梅 吴斐华 

机构地区：[1]中国药科大学中药学院,中药药理与中医药学系,江苏 南京

出　　处：《药物资讯》2024年第2期48-55,共8页Pharmacy Information

摘　　要：过氧化物酶体是真核细胞中保守的细胞器,是哺乳动物中调控氧化还原和脂质稳态的重要枢纽。过氧化物酶体在细胞脂质和活性氧的代谢中具有关键作用,对人类健康和发育至关重要。过氧化物酶体途径的调节主要与过氧化物酶体群的数量变化有关,其稳态的动态变化主要通过过氧化物酶体生物发生和选择性自噬维持。过氧化物酶体功能异常不仅导致过氧化物酶体生物发生障碍疾病,还与许多其他人类疾病有关,如神经退行性疾病、癌症、衰老和糖尿病等。Peroxisome is a conserved organelle in eukaryotic cells and an important hub for regulating redox and lipid homeostasis in mammals. Peroxisomes play a key role in the metabolism of cellular lipids and reactive oxygen species and are essential for human health and development. The regulation of the peroxisome pathway is mainly related to the change of the number in peroxisome groups, and the dynamic change of its homeostasis is mainly regulated by peroxisome biogenesis and pexophagy. Peroxisome dysfunction not only leads to peroxisome biogenesis disorders but also is associated with many other human diseases, such as neurodegenerative diseases, cancer, aging, and diabetes.

关 键 词：过氧化物酶体生物发生 过氧化物酶体自噬 齐薇格谱系障碍 神经退行性疾病 

分 类 号：R73[医药卫生—肿瘤]