靶向调控毛囊干细胞功能治疗雄激素脱发的研究进展  

Research Progress on Targeted Regulation of Hair Follicle Stem Cell Function in the Treatment of Androgenetic Alopecia

作　　者：胡婕 胡韫伟 张晓雅 梁嘉莹 吴建新[1] 黄庆 

机构地区：[1]中国药科大学中药学院,江苏 南京

出　　处：《药物资讯》2024年第3期187-197,共11页Pharmacy Information

摘　　要：雄激素脱发(androgenetic alopecia, AGA)是一种最常见的脱发类型。通过靶向调控毛囊干细胞功能改善AGA是近年来的研究热点,毛囊干细胞在调节毛囊周期生长中起着至关重要的作用,具体调控策略包括:调节毛囊干细胞微环境、干预信号传导与生长因子表达等。本篇综述基于AGA的发病机制,总结了近年来靶向调控毛囊干细胞治疗AGA的相关研究,讨论了此种策略对于治疗AGA的可能性及优势,以期为进一步研究及临床应用提供参考。Androgenetic alopecia (AGA) is one of the most common types of hair loss. Hair follicle stem cells play a vital role in regulating the growth of hair follicle cycle, and the specific regulatory strategies include: regulating the microenvironment of hair follicle stem cells, intervening in signaling and growth factor expression, etc. This review explores the pathogenesis of AGA, summarizes the recent research on targeting and regulating hair follicle stem cells, as well as the possibilities and advantages of this strategy for the treatment of AGA, with a view to providing reference for further research and clinical application.

关 键 词：雄激素脱发 毛囊上皮干细胞 真皮毛乳头细胞 机制 

分 类 号：R73[医药卫生—肿瘤]