特异性促炎症消退介质干预溃疡性结肠炎的研究进展  

Specialized Pro-Resolving Mediators: Unveiling Their Role in Ulcerative Colitis

作　　者：郭鹏翔 戴岳 

机构地区：[1]中国药科大学中药学院中药药理与中医药学系,江苏 南京

出　　处：《药物资讯》2024年第4期398-404,共7页Pharmacy Information

摘　　要：近年来,特异性促炎症消退介质(SPMs)对溃疡性结肠炎(UC)的影响日益受到关注。SPMs通过加速中性粒细胞清除、促进胞葬和修复上皮缺损等途径,促进结肠炎症的消退。本文就SPMs的分类及作用进行综述,关注其在UC中的最新研究进展,旨在为揭示UC的发病机制和构建靶向治疗策略提供参考。Recently, there has been a growing focus on the role of specialized pro-resolving mediators (SPMs) in ulcerative colitis (UC). SPMs facilitate the resolution of colonic inflammation by accelerating neutrophil clearance, promoting efferocytosis, and facilitating epithelial repair. These functions offer novel insights into the treatment of UC. This article provides a comprehensive review of the classification and mechanisms of action of SPMs. It also summarizes the latest research advances in their role in UC. The aim is to establish a theoretical basis and suggest new research directions for future therapeutic strategies.

关 键 词：特异性促炎症消退介质 溃疡性结肠炎 消退素 脂氧素 保护素 

分 类 号：R57[医药卫生—消化系统]