原人参二醇及Compound K抑制肝细胞肝癌的作用及机制  

The Inhibitory Effect of Protopanoxadiol and Compound K on Hepatocellular Carcinoma and the Underlying Mechanisms

作　　者：张春蕾 宋海燕 许阳贤[2] 季光 

机构地区：[1]上海中医药大学附属龙华医院脾胃病研究所,上海 [2]上海中医药大学附属龙华医院普外科,上海

出　　处：《中医学》2017年第2期104-109,共6页Traditional Chinese Medicine

基　　金：国家自然科学基金(81573894,81202667);中西医结合人才计划(ZY3-RCPY-4-2014)。

摘　　要：中晚期肝癌及术后复发转移性肝癌目前仍然缺乏有效治疗手段。原人参二醇(protopanoxadiol, PPD)及人参皂苷Compound K是二醇型人参皂苷在体内的代谢产物。近年来多项研究发现这两种天然产物可通过诱导细胞凋亡、抑制细胞增殖、抑制血管生成、抑制转移等机制对多种肿瘤发挥抑瘤效应。其中对肝细胞肝癌的作用研究较多,抑癌效果尤为突出。本文就近年来PPD及Compound K抗肝细胞肝癌的作用和相关机制研究进行系统综述,以期有助于开发出有效治疗肝癌的天然药物。There is still no effective treatment available for advanced liver cancer or the recurrence and me-tastasis after surgical resection. Protopanoxadiol (PPD) and ginsenoside Compound K are the me-tabolites of protopanaxadiol-type ginsenosides in vivo. In recent years, a number of studies have found that these two kinds of natural products could play a role of tumor suppression through in-ducing cell apoptosis, inhibiting cell proliferation, inhibiting angiogenesis and limiting tumor cell metastasis. Among them, there are many studies focusing on the effect of PPD or Compound K on hepatocellular carcinoma (HCC), in which the anti-cancer effect is prominent. This paper reviews the recent studies on the role of PPD/Compound K in HCC and the related mechanisms, in order to ben-efit the development of new effective natural medicine to treat HCC.

关 键 词：肝细胞肝癌 原人参二醇 COMPOUND K 

分 类 号：R73[医药卫生—肿瘤]