探索中西医治疗国内前十种常见癌症的临床疗效  

Meta-Analysis of Combined Treatment of Integrated Traditional Chinese Medicine and Western Medicine in Treatment of Top 10 Cancers in the World

作　　者：欧韵怡 陈海勇[1,2,3] 俞瑾 朱南孙[3,6] 孟炜 

机构地区：[1]香港大学中医药学院,香港 [2]香港大学中医药学院,中西医结合妇科教研基地(香港分中心)俞瑾名中医传承工作站,香港 [3]香港大学中医药学院,海派朱氏妇科流派基地(香港分中心)朱南孙国医大师传承工作站,香港 [4]上海复旦大学妇产科医院,上海 [5]上海泰坤堂中医院,上海 [6]上海中医药大学附属岳阳中西结合医院,上海

出　　处：《中医学》2021年第6期807-822,共16页Traditional Chinese Medicine

摘　　要：目的:本研究采用系统评价及Meta分析方法,探索中医治疗全球前十种常见癌症的临床疗效。方法:使用计算机检索中国知网数据库自2010年1月至2021年6月有关中医药治疗全球前十种常见肿瘤的临床随机对照(RCT)研究。按照设定纳入排除标准筛选文献后,应用Cochrane偏倚风检评估工具进行偏倚风检评估,并采用Review Manager 5.4.1软件对数据进行Meta分析。结果:本研究共纳入80篇临床随机对照试验文献。中西医合壁治疗试验组总缓解率为55.5%。较单纯西医对照组总缓解率40.1%为高。Meta分析显示与单纯西医药对照组相比,配合使用中医药治疗更能缓解肿瘤[OR = 2.01, 95% CI (1.80, 2.24), P 【0.05]。结论:中西医联合治疗肿瘤的总缓解率,优于单纯使用西医药治疗,且差异具有统计学上的意义。Objective: To systematically investigate the clinical effect of combined treatment of integrated traditional Chinese Medicine (TCM) and Western Medicine in treating the top 10 cancers in the world. Methods: Randomized controlled trials (RCTs) of TCM and Western Medicine therapy of each top 10 cancers dated from January 2010 to June 2021 were searched from the China jour-nal full text database (CNKI). After screening the literatures according to the defined exclusion criteria, the Cochrane risk-of-bias tool was adopted to conduct bias risk assessment. Review manager 5.4.1 software was then used for carrying out Meta-analysis. Results: 80 numbers of RCTs were ultimately selected after screening in accordance with the defined exclusion criteria. Meta-analysis showed that the total efficiencies of control group (i.e. with Western Medicine treatment) and experimental group (i.e. with combined TCM and Western Medicine treatment) are 40.1% and 55.5% respectively. This indicated that, compared with the control group, the overall efficiency of combined TCM and Western Medicine treatment is higher and the difference is statistically significant [OR = 2.01, 95%CI (1.80, 2.24), P <0.05]. Conclusion: The combined TCM and Western Medicine therapy shows improvement on the overall efficiency when com-paring with the control group that adopts the Western Medicine, and the difference is statisti-cally significant.

关 键 词：常见肿瘤 手术 化疗 中医 中药 META分析 

分 类 号：R73[医药卫生—肿瘤]