抗肝衰复方联合人工肝治疗对慢加急性肝衰竭湿热瘀阻证患者血清炎症因子及预后的影响  

Effect of Anti-Liver Failure Compound Combined with Artificial Liver Treatment on Serum Inflammatory Factors and Prognosis in Patients with Damp Heat and Blood Stasis Syndrome in Acute-on-Chronic Liver Failure

作　　者：冯雨薇 张建军[1] 戴丹 黄橘村 

机构地区：[1]江汉大学附属湖北省第三人民医院中西医结合肝病科,湖北 武汉

出　　处：《中医学》2024年第12期3308-3314,共7页Traditional Chinese Medicine

基　　金：第七批全国老中医药专家学术经验继承指导项目。

摘　　要：目的:观察抗肝衰复方联合人工肝治疗对慢加急性肝衰竭(ACLF)患者血清降钙素原(PCT)、白介素-6 (IL-6)、血清丛生蛋白(Clusterin)、趋化因子受体5 (CCR5)和预后的影响。方法:85例慢加急性肝衰竭患者随机分成两组,其中试验组43例,对照组42例;两组患者均给予人工肝治疗及常规西医治疗,试验组在此基础上加用抗肝衰复方治疗;治疗疗程为4周,并在第12周随访,比较两组治疗前后中医证候评分、肝功能指标、凝血功能指标、炎症因子指标及预后结局。结果:试验组治疗后乏力、腹胀中医证候积分及总积分、MELD评分比对照组同期更低(p p p > 0.05);试验组血清PCT、IL-6、Clusterin、CCR5均较治疗前明显好转,差异具有统计学意义(p p p Objective: Observe the effect of anti-liver failure compound combined with artificial liver on serum procalcitonin (PCT), interleukin-6 (IL-6), serum clusterin, chemokine receptor 5 (CCR5), and prognostic implications in patients with acute-on-chronic liver failure. Methods: 85 patients with acute-on-chronic liver failure were randomly divided into two groups, including 43 cases in the experimental group and 42 cases in the control group. Both groups of patients were given artificial liver treatment and conventional Western medicine treatment, and the experimental group was additionally treated with an anti-liver failure compound;the treatment course was 4 weeks, and follow-up was conducted in the 12th week. The TCM syndrome scores, liver function indicators, coagulation function indicators, inflammatory factor indicators, and prognosis outcomes were compared between the two groups before and after treatment. Results: After treatment, the experimental group’s fatigue, abdominal distension, TCM syndrome scores, total scores, and MELD scores were lower than those of the control group during the same period (p p p > 0.05);the serum PCT, IL-6, Clusterin, and CCR5 in the experimental group were significantly improved compared w

关 键 词：慢加急性肝衰竭 抗肝衰复方 中西医结合治疗 

分 类 号：R73[医药卫生—肿瘤]