NLRP3炎症小体在抑郁症发病机制中的作用及中药干预的研究  

The Role of NLRP3 Inflammasome in the Pathogenesis of Depression and the Intervention of Traditional Chinese Medicine

作　　者：沈炜坤 

机构地区：[1]黑龙江省中医药科学院中药研究所,黑龙江 哈尔滨

出　　处：《中医学》2025年第1期58-66,共9页Traditional Chinese Medicine

摘　　要：抑郁症的发病机制与炎症小体,特别是NLRP3炎症小体的激活密切相关,炎症反应在抑郁症的发生和发展中发挥着关键作用。中药通过抑制NLRP3炎症小体的活性及其相关促炎因子的表达,显示出显著的抗抑郁效果,且其机制涉及神经递质的调节、神经营养因子的提升以及HPA轴的调控。未来的研究应进一步探讨中药对炎症小体的具体调控机制,并推动其在临床应用中的个体化治疗策略,以期为抑郁症的防治提供新的思路。The pathogenesis of depression is closely related to the inflammasome, particularly the activation of the NLRP3 inflammasome. Inflammatory responses play a critical role in the onset and progression of depression. Traditional Chinese medicine has demonstrated significant antidepressant effects by inhibiting the activity of the NLRP3 inflammasome and the expression of its related pro-inflammatory factors. The mechanisms involved include the regulation of neurotransmitters, the enhancement of neurotrophic factors, and the modulation of the HPA axis. Future research should further investigate the specific regulatory mechanisms of traditional Chinese medicine on the inflammasome and promote individualized treatment strategies in clinical applications, with the aim of providing new perspectives for the prevention and treatment of depression.

关 键 词：抑郁症 NLRP3炎症小体 中药 神经递质 HPA轴 

分 类 号：R74[医药卫生—神经病学与精神病学]