非甾体类抗炎药的临床应用与消化道损害  

Clinical Use of Nonsteroidal Anti-Inflammatory Drugs and Gastrointestinal Tract Damage

作　　者：吕梦鸽 何俊彪 石莉杰 毋亚男 李艳英 李雪微 张颖 黄天生 

机构地区：[1]上海中医药大学附属光华医院,上海 [2]上海中医药大学附属光华医院消化内科,上海

出　　处：《中医学》2025年第1期253-260,共8页Traditional Chinese Medicine

基　　金：上海市长宁区卫健委课题(20214Z002)。

摘　　要：非甾体抗炎药是临床最常用的药物之一,在抗炎、解热、镇痛等方面疗效显著,此外,NSAIDs还被进一步证明可以预防多种严重疾病,包括癌症和心脏病发作。然而,多项研究数据表明NSAIDs会对胃肠道造成损害。本综述提供了NSAIDs的临床应用与引起的胃肠道损伤,旨在不损害临床益处的情况下更安全地使用NSAIDs。Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used drugs in the clinic, with significant efficacy in anti-inflammatory, antipyretic, and analgesic effects, in addition to NSAIDs being further proven to prevent a wide range of serious illnesses, including cancer and heart attacks. However, data from several studies suggest that NSAIDs can cause damage to the gastrointestinal tract. This review provides clinical applications of NSAIDs with induced gastrointestinal damage and aims to use NSAIDs more safely without compromising clinical benefits.

关 键 词：非甾体抗炎药 胃肠道 类风湿性关节炎 骨关节炎 

分 类 号：R57[医药卫生—消化系统]