EB病毒相关淋巴瘤研究进展  

Research Progress of Epstein Barr Virus Associated Lymphoma

作　　者：郝园园 林森森[1] 

机构地区：[1]中国药科大学,江苏 南京

出　　处：《世界肿瘤研究》2021年第2期38-47,共10页World Journal of Cancer Research

摘　　要：Eb病毒(Epstein-Barr virus, EBV)属疱疹病毒群,为双链DNA病毒,超过90%的成年人为EBV健康携带者,尽管在绝大多数携带者中无害,EBV却以不同比例存在于多种免疫力看似正常的不同类型淋巴瘤及上皮细胞肿瘤患者的癌细胞中,包括伯基特淋巴瘤、霍奇金淋巴瘤、弥漫大B细胞淋巴瘤等。EBV相关淋巴瘤的发病机理与病毒基因表达及细胞基因表达间存在着复杂的关系,现就几种常见淋巴瘤中EBV的作用机制及相关研究进展进行综述。Epstein Barr virus (EBV) is a new type of virus. EBV belongs to herpesvirus group, which is double stranded DNA virus. More than 90% of adults are healthy EBV carriers. Although it is harmless in most of the carriers, EBV exists in different proportions in cancer cells of different types of lymphoma and epithelial cell tumor patients with normal immunity, including Burkitt’s lymphoma, Hodgkin’s lymphoma, diffuse large B-cell lymphoma, etc. There is a complex relationship between the pathogenesis of EBV associated lymphoma and the gene expression of virus and cell. This article reviews the mechanism of EBV in several common lymphomas and the related research progress.

关 键 词：EB病毒 伯基特淋巴瘤 霍奇金淋巴瘤 弥漫大B细胞淋巴瘤 

分 类 号：R73[医药卫生—肿瘤]