冠心病患者血清TLR4水平增高及其与TLR4基因突变和临床的关系的研究  

Study on the Relationship between the Increased Serum TLR4 Level and TLR4 Gene Mutation and Clinic in Patients with Coronary Heart Disease

作　　者：黄达[1] 潘兴寿[1] 邹才华[2] 梁烨[3] 李天资[1] 李近都 

机构地区：[1]右江民族医学院附属医院心内科,广西 百色 [2]右江民族医学院附属医院腺体外科,广西 百色 [3]右江民族医学院附属医院教学部,广西 百色 [4]广西医科大学附属肿瘤医院肝胆胰脾外科,广西 南宁

出　　处：《亚洲心脑血管病例研究》2023年第2期9-16,共8页Asian Case Reports in Vascular Medicine

摘　　要：目的:探讨冠心病患者血清TLR4水平增高及其与TLR4基因突变和临床的关系。方法:选取PCI术的冠心病患者286例,检测血清TLR4水平,将TLR4 ≥ 3.50 ng/ml列入高水平组,<3.5 ng/ml列入低水平组,比较两组患者的体质指数(BMI)、血压、血脂、血糖、血尿酸、C反应蛋白(CRP)、β2微球蛋白(β2MG)、白细胞介素6 (IL6)和toll样受体4 (TLR4)基因rs4986790、rs4986791位点碱基水平。结果:血清TLR4高水平组TLR4基因突变率高于低水平组,TLR4高水平组患者BMI、收缩压、总胆固醇、甘油三酯、空腹血糖、血尿酸、β2MG、CRP、IL6水平高于低水平组(P < 0.01或P < 0.05)。结论:血清TLR4水平增高的冠心病患者其TLR4基因突变率高,代谢紊乱,炎症因子活跃。Objective: To investigate the relationship between the increased level of serum TLR4 and TLR4 gene mutation in patients with coronary heart disease (CHD). Methods: Serum TLR4 levels were measured in 286 patients with coronary heart disease undergoing PCI. Patients with TLR4 ≥ 3.50 ng/ml were classified as a high-level group, and those with TLR4 ≥ 3.5 ng/ml were classified as low level group, body mass index (BMI), blood pressure, blood lipids, blood glucose, serum uric acid, c-reactive protein (CRP), β2 microglobulin (β2 MG), interleukin 6 (IL6) and RS4986790, RS4986791 of toll-like receptor 4 (TLR4) gene were compared between the two groups. Results: The mutation rate of the TLR4 gene in the high-level group was higher than that in the low-level group, the levels of BMI, systolic blood pressure, total cholesterol, triglyceride, fasting blood glucose, serum uric acid, β2 mg, CRP and IL-6 were higher in the high TLR4 group than in the low TLR4 group (P & Lt;0.01 or P & Lt;0.05). Conclusion: Patients with high serum TLR4 levels have a high mutation rate of the TLR4 gene, metabolic disorder and active inflammatory factors.

关 键 词：冠状动脉狭窄 介入治疗反应 支架内再狭窄 toll受体4 基因突变 

分 类 号：R54[医药卫生—心血管疾病]