Clinical Experience and Dosimetry Outcome in Treating Breast Cancer with Field-in-Field Technique  

作　　者：Bidyapati Jha Hari Prasad Lamichhane GisupNikha Prasiko Raju Prasad Srivastava Bidyapati Jha;Hari Prasad Lamichhane;GisupNikha Prasiko;Raju Prasad Srivastava(Department of Radiation Oncology, Bhaktapur Cancer Hospital, Dudhpati, Bhaktapur, Nepal;Central Department of Physics, Institute of Science & Technology, Tribhuvan University, Kirtipur, Kathmandu, Nepal;Nepal Cancer Hospital and Research Center, Harsiddhi, Latitpur, Nepal;Department of Radiation Oncology, Ghent University Hospital, Corneel Heymanslaan, Ghent, Belgium)

机构地区：[1]Department of Radiation Oncology, Bhaktapur Cancer Hospital, Dudhpati, Bhaktapur, Nepal [2]Central Department of Physics, Institute of Science & Technology, Tribhuvan University, Kirtipur, Kathmandu, Nepal [3]Nepal Cancer Hospital and Research Center, Harsiddhi, Latitpur, Nepal [4]Department of Radiation Oncology, Ghent University Hospital, Corneel Heymanslaan, Ghent, Belgium

出　　处：《Advances in Breast Cancer Research》2021年第3期35-43,共9页乳腺癌（英文）

摘　　要：<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">The study is aimed to establish the dosimetric characteristics of field-in-field (FiF) technique for carcinoma of breast treatment in Nepal. We assumed that FIF technique may result in improved dose distribution and reduced acute toxicity in these patients. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Forty breast cancer patient</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> participated in this study. A total dose of 50 Gy in 25 fractions was prescribed to the planning target volume. FiF plan was generated in treatment planning system. Dose volume histograms w</span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> evaluated for PTV and organs at risks. Several parameters were analyzed for the PTVs and organ at risks (OARs) together with the Conformity index (CI), and the Homogeneity index (HI). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The dose coverage of breast volume was achieved. The V</span>_{<span style="font-family:Verdana;">95%</span>}<span style="font-family:Verdana;"> (volume of 95%) of PTV covered D</span>_{<span style="font-family:Verdana;">95%</span>}<span style="font-family:Verdana;"> (Dose of 95%). The PTV dose was covered to 49.98 ± 0.9 Gy and 49.81 ± 1.1 Gy for the left and right breast, respectively. The mean lung dose was 14.87 ± 0.91 Gy. The homogeneity index (0.26 ± 0.17 and 0.22 ± 0.13) and conformity index (1.59 ± 0.75 and 1.36 ± 0.45) were analyzed for left and right breast, respectively. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">The study supports the viability of FiF technique in the treatment of breast cancer in Nepal. The FIF technique enables better dose distribution in the PTV and reduces dose to OA<strong>Purpose:</strong> <span style="font-family:""><span style="font-family:Verdana;">The study is aimed to establish the dosimetric characteristics of field-in-field (FiF) technique for carcinoma of breast treatment in Nepal. We assumed that FIF technique may result in improved dose distribution and reduced acute toxicity in these patients. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">Forty breast cancer patient</span></span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> participated in this study. A total dose of 50 Gy in 25 fractions was prescribed to the planning target volume. FiF plan was generated in treatment planning system. Dose volume histograms w</span><span style="font-family:Verdana;">ere</span><span style="font-family:""><span style="font-family:Verdana;"> evaluated for PTV and organs at risks. Several parameters were analyzed for the PTVs and organ at risks (OARs) together with the Conformity index (CI), and the Homogeneity index (HI). </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">The dose coverage of breast volume was achieved. The V</span>_{<span style="font-family:Verdana;">95%</span>}<span style="font-family:Verdana;"> (volume of 95%) of PTV covered D</span>_{<span style="font-family:Verdana;">95%</span>}<span style="font-family:Verdana;"> (Dose of 95%). The PTV dose was covered to 49.98 ± 0.9 Gy and 49.81 ± 1.1 Gy for the left and right breast, respectively. The mean lung dose was 14.87 ± 0.91 Gy. The homogeneity index (0.26 ± 0.17 and 0.22 ± 0.13) and conformity index (1.59 ± 0.75 and 1.36 ± 0.45) were analyzed for left and right breast, respectively. </span><b><span style="font-family:Verdana;">Conclusion: </span></b><span style="font-family:Verdana;">The study supports the viability of FiF technique in the treatment of breast cancer in Nepal. The FIF technique enables better dose distribution in the PTV and reduces dose to OA

关 键 词：Field in Field (FiF) Planning Target Volume (PTV) Treatment Planning Sys-tem (TPS) Homogeneity Index (HI) Conformity Index (CI) 

分 类 号：R73[医药卫生—肿瘤]