Impact of Praziquantel on Schistosomiasis Infection and the Status of Proteinuria and Hematuria among School Children Living in Schistosoma mansoni-Endemic Communities in Northwestern Tanzania  

作　　者：Neema Kayange Benson R. Kidenya Charles Muiruri Bahati Wajanga Karl Reis Rune Nathaniel Philemon Baraka Revocatus Evarist Msaki John Bartlett Humphrey D. Mazigo Neema Kayange;Benson R. Kidenya;Charles Muiruri;Bahati Wajanga;Karl Reis;Rune Nathaniel Philemon;Baraka Revocatus;Evarist Msaki;John Bartlett;Humphrey D. Mazigo(Department of Pediatrics, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania;Department of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania;Department of Population Health Sciences, Duke University, Durham, USA;Department of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania;Centre for Global Health at Weill Cornell, New York, USA;Department of Paediatrics and Child Health, Kilimanjaro Christian Medical Centre, Moshi, Tanzania, Kilimanjaro Christian Medical University College, Moshi, Tanzania;Department of Community Health, Consultancy and Research Services, Bugando Medical Centre, Mwanza, Tanzania;Department of Epidemiology and Biostatistics, Bugando Medical Centre, Mwanza Tanzania, Tanzania;Duke Global Health Institute, Duke University, Durham, USA;Department of Medical Parasitology and Entomology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania)

机构地区：[1]Department of Pediatrics, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania [2]Department of Biochemistry and Molecular Biology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania [3]Department of Population Health Sciences, Duke University, Durham, USA [4]Department of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania [5]Centre for Global Health at Weill Cornell, New York, USA [6]Department of Paediatrics and Child Health, Kilimanjaro Christian Medical Centre, Moshi, Tanzania, Kilimanjaro Christian Medical University College, Moshi, Tanzania [7]Department of Community Health, Consultancy and Research Services, Bugando Medical Centre, Mwanza, Tanzania [8]Department of Epidemiology and Biostatistics, Bugando Medical Centre, Mwanza Tanzania, Tanzania [9]Duke Global Health Institute, Duke University, Durham, USA [10]Department of Medical Parasitology and Entomology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, United Republic of Tanzania

出　　处：《Advances in Infectious Diseases》2022年第3期448-465,共18页传染病进展（英文）

摘　　要：The aim of the study was to assess the effect of praziquantel (PZQ) treatment on hematuria, proteinuria and the status of eGFR following treatment in school children infected with S. mansoni. A cohort study among 6 - 13 years old children was conducted in the Lake Zone region of Tanzania to assess S. mansoni infection using a circulating cathodic antigen (CCA), Kato Kartz while urine dipstick to screen for urine protein levels and red blood cells. A blood sample was taken for every child to determine creatinine levels and later a status of estimated glomerular filtration rate (eGFR). The prevalence of S. mansoni infection was 64%, 46%, and 24% at baseline, 6 months, and 1 year respectively using CCA test. There was a 62.5% reduction in S. mansoni infection from baseline (p S. mansoni using CCA test, reductions in proteinuria, and hematuria in school children in Tanzania. There was complete remission in eGFR < 90 ml/min/1.73 m² from 3.9% to 0% at 6 months. This suggests that praziquantel is effective, but there is still a need for integrated strategies to minimize reinfections.The aim of the study was to assess the effect of praziquantel (PZQ) treatment on hematuria, proteinuria and the status of eGFR following treatment in school children infected with S. mansoni. A cohort study among 6 - 13 years old children was conducted in the Lake Zone region of Tanzania to assess S. mansoni infection using a circulating cathodic antigen (CCA), Kato Kartz while urine dipstick to screen for urine protein levels and red blood cells. A blood sample was taken for every child to determine creatinine levels and later a status of estimated glomerular filtration rate (eGFR). The prevalence of S. mansoni infection was 64%, 46%, and 24% at baseline, 6 months, and 1 year respectively using CCA test. There was a 62.5% reduction in S. mansoni infection from baseline (p S. mansoni using CCA test, reductions in proteinuria, and hematuria in school children in Tanzania. There was complete remission in eGFR < 90 ml/min/1.73 m² from 3.9% to 0% at 6 months. This suggests that praziquantel is effective, but there is still a need for integrated strategies to minimize reinfections.

关 键 词：IMPACT Schistosoma mansoni School-Aged Children Tanzania 

分 类 号：R73[医药卫生—肿瘤]