Visceral Leishmaniasis at the National Reference University Hospital Center of N’Djamena (Chad): Epidemiological, Clinical, Diagnostic, Therapeutic and Prognostic Aspects  

作　　者：Joseph Mad-Toïngué Mahamat Ali Ahmat Oumaïma Mahamat Djarma Alifa Adjibera Philippe Ali Mahamat Moussa Ngakoutou Rangar Choua Ouchemi Mahamat Ali Bolti Djiddi Ali Sougoudi Mamissou Didi Mahamat Doungous Atim Joseph Mad-Toïngué;Mahamat Ali Ahmat;Oumaïma Mahamat Djarma;Alifa Adjibera Philippe;Ali Mahamat Moussa;Ngakoutou Rangar;Choua Ouchemi;Mahamat Ali Bolti;Djiddi Ali Sougoudi;Mamissou Didi;Mahamat Doungous Atim(Service des Maladies Infectieuses, CHU de Référence Nationale, N’Djamena, Chad;Service de Gastroentérologie et Médecine Interne, CHU de Référence Nationale, N’Djamena, Chad;Service de Pneumologie et Phtisiologie, CHU de Référence Nationale, N’Djamena, Chad;Service de Chirurgie viscérale, CHU de Référence Nationale, N’Djamena, Chad;Service de Médecine, CHU de la Renaissance, N’Djamena, Chad)

机构地区：[1]Service des Maladies Infectieuses, CHU de Référence Nationale, N’Djamena, Chad [2]Service de Gastroentérologie et Médecine Interne, CHU de Référence Nationale, N’Djamena, Chad [3]Service de Pneumologie et Phtisiologie, CHU de Référence Nationale, N’Djamena, Chad [4]Service de Chirurgie viscérale, CHU de Référence Nationale, N’Djamena, Chad [5]Service de Médecine, CHU de la Renaissance, N’Djamena, Chad

出　　处：《Advances in Infectious Diseases》2024年第2期478-486,共9页传染病进展（英文）

摘　　要：Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases Department of the Centre Hospitalier Universitaire de Référence Nationale in N'Djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases Department of the Centre Hospitalier Universitaire de Référence Nationale in N'Djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关 键 词：Visceral Leishmaniasis Gold Mining Sites CHAD 

分 类 号：R73[医药卫生—肿瘤]