Impact of Preoperative Serum Tumor Markers in Patients with Lung Squamous Cell Carcinoma  

作　　者：Masaki Tomita Shoei Kuroki Tomoka Hamahiro Ryo Maeda Takanori Ayabe Masaki Tomita;Shoei Kuroki;Tomoka Hamahiro;Ryo Maeda;Takanori Ayabe(Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan)

机构地区：[1]Department of Thoracic and Breast Surgery, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, Japan

出　　处：《Advances in Lung Cancer》2021年第3期48-55,共8页肺癌（英文）

摘　　要：<b>Background:</b> Several previous researchers have investigated the prognostic value of serum tumor markers, especially carcinoembryonic antigen (CEA). Only a limited number of studies reported the usefulness of serum tumor markers for lung squamous cell carcinoma (SQ). We aimed to examine the significance of serum tumor markers for lung SQ. <b>Methods:</b> Eighty-five lung SQ patients who underwent surgery and followed more than 5-year were included. The ratios of 5-year survivors to all patients in groups with several clinicopathologic factors, including tumor markers, were compared. We also compared the clinicopathologic factors between central type and peripheral type SQ. <b>Results:</b> The majority of patients were male gender and current/ former smokers. Age, pN status, cytokeratin-19 fragment (CYFRA 21-1), squamous cell carcinoma antigen (SCC), and comorbid interstitial pneumonia (IP) were associated with the ratio of 5-year survivors significantly. When patients were compared based on tumor location, high p-stage and CYFRA 21-1 were related to central type SQ. <b>Conclusion:</b> Both SCC and CYFRA 21-1 appeared to be useful prognostic markers for patients with lung SQ. Furthermore, CYFRA 21-1 was related to central type SQ.<b>Background:</b> Several previous researchers have investigated the prognostic value of serum tumor markers, especially carcinoembryonic antigen (CEA). Only a limited number of studies reported the usefulness of serum tumor markers for lung squamous cell carcinoma (SQ). We aimed to examine the significance of serum tumor markers for lung SQ. <b>Methods:</b> Eighty-five lung SQ patients who underwent surgery and followed more than 5-year were included. The ratios of 5-year survivors to all patients in groups with several clinicopathologic factors, including tumor markers, were compared. We also compared the clinicopathologic factors between central type and peripheral type SQ. <b>Results:</b> The majority of patients were male gender and current/ former smokers. Age, pN status, cytokeratin-19 fragment (CYFRA 21-1), squamous cell carcinoma antigen (SCC), and comorbid interstitial pneumonia (IP) were associated with the ratio of 5-year survivors significantly. When patients were compared based on tumor location, high p-stage and CYFRA 21-1 were related to central type SQ. <b>Conclusion:</b> Both SCC and CYFRA 21-1 appeared to be useful prognostic markers for patients with lung SQ. Furthermore, CYFRA 21-1 was related to central type SQ.

关 键 词：Lung Squamous Cell Carcinoma Cytokeratin-19 Fragment Squamous Cell Carcinoma Antigen 

分 类 号：R73[医药卫生—肿瘤]