Potential of <i>Syzygium aromaticum</i>(Clove) Leaf Extract on Immune Proliferation Response in Balb/c Mice Infected with <i>Salmonella typhimurium</i>  

作　　者：Syahran Wael Theopilus Wilhelmus Watuguly Ine Arini Alwi Smit Nur Matdoan Dwi Retna Prihati Ana Bina Sari Didik Wahyudi Tri Rini Nuringtyas Nastiti Wijayanti Pudji Astuti 

机构地区：[1]Department of Biology, Universitas Pattimura, Kota Ambon, Indonesia [2]Department of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia [3]Department of Midwifery, Poltekkes Kemenkes Surakarta, Klaten, Indonesia [4]Department of Medical Diagnostics, Bakti Asih College of Health, Bandung, Indonesia [5]Department of Medical Laboratory Technology, National College of Health, Solo, Indonesia [6]Department of Veterinary Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia

出　　处：《Case Reports in Clinical Medicine》2018年第12期613-627,共15页临床医学病理报告（英文）

摘　　要：Background and Objective: Syzygium aromaticum is an immunomodulator with the main active compound eugenol which can stimulate the function of lymphocyte proliferation and macrophage production. Lymphocytes play an important role for body protection against infection. This study aims to analyze the effect of S. aromaticum extract to increase proliferation of lymphocytes, lymphoblasts and macrophage production in Balb/c mice infected with Salmonella typhimurium. Methodology: Mice strain Balb/c were divided into 4 groups: treatment group infected with S. typhimurium and control group (without treatment) to tested the activity of peritoneal macrophages. The treatment group was administrated by S. aromaticum leaf extract (15 mg, 75 mg, 150 mg/kgbw) for 12 days. Results: S. aromaticum leaf extract increased the proliferation activity (p Conclusion: Administration of S. aromaticum leaf extract increased the proliferation activity of lymphocytes, lymphoblasts and ROI secretion of macrophagesin Balb/c mice infected with S. typhimurium.Background and Objective: Syzygium aromaticum is an immunomodulator with the main active compound eugenol which can stimulate the function of lymphocyte proliferation and macrophage production. Lymphocytes play an important role for body protection against infection. This study aims to analyze the effect of S. aromaticum extract to increase proliferation of lymphocytes, lymphoblasts and macrophage production in Balb/c mice infected with Salmonella typhimurium. Methodology: Mice strain Balb/c were divided into 4 groups: treatment group infected with S. typhimurium and control group (without treatment) to tested the activity of peritoneal macrophages. The treatment group was administrated by S. aromaticum leaf extract (15 mg, 75 mg, 150 mg/kgbw) for 12 days. Results: S. aromaticum leaf extract increased the proliferation activity (p Conclusion: Administration of S. aromaticum leaf extract increased the proliferation activity of lymphocytes, lymphoblasts and ROI secretion of macrophagesin Balb/c mice infected with S. typhimurium.

关 键 词：SYZYGIUM aromaticum Lymphocytes LYMPHOBLAST Macrophage Salmonella TYPHIMURIUM 

分 类 号：R73[医药卫生—肿瘤]