Transformation of Malignant Phyllodes Tumors into Benign Tumors in Tumor Recurrence: A Case Report  

作　　者：Mohammad Mahdi Talimkhani Ali Yamini Leili Ebrahimi Farsangi Aida Alizamir Shaghayegh Shamekhi Mohammad Mahdi Gholami Mohamad Reza Javadi Mohammad Mahdi Talimkhani;Ali Yamini;Leili Ebrahimi Farsangi;Aida Alizamir;Shaghayegh Shamekhi;Mohammad Mahdi Gholami;Mohamad Reza Javadi(School of Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran;Ward of Surgery, Besat Hospital, Hamadan, Iran;Department of Cardiology, Albirz University of Medical Science, Karaj, Iran;Department of Pathology, School of Medicine, Hamedan University of Medical Science, Hamadan, Iran;Department of General Surgery, Hamadan University of Medical Sciences, Hamadan, Iran)

机构地区：[1]School of Medicine, Student Research Committee, Hamadan University of Medical Sciences, Hamadan, Iran [2]Ward of Surgery, Besat Hospital, Hamadan, Iran [3]Department of Cardiology, Albirz University of Medical Science, Karaj, Iran [4]Department of Pathology, School of Medicine, Hamedan University of Medical Science, Hamadan, Iran [5]Department of General Surgery, Hamadan University of Medical Sciences, Hamadan, Iran

出　　处：《Case Reports in Clinical Medicine》2024年第12期558-565,共8页临床医学病理报告(英文)

摘　　要：Objective: Phyllodes tumors (PTs) are rare, distinctive fibroepithelial neoplasms. They are associated with a low incidence and comprise 0.3% - 0.9% of all breast tumors. Recurrence occurs in about 20% of cases, and malignant PTs exhibit a higher rate of early recurrence than benign ones. The transformation from malignant to benign PTs is extremely rare. Here, we presented the case of a 29-year-old woman diagnosed with a malignant PT that transformed into a benign Within six months after excisional surgery. Materials and Methods: This is a case report. Results: A 29-year-old woman presented to our hospital with left breast enlargement, which was not accompanied by pain or discharge. An ultrasound revealed a heterogeneous, solid mass. She underwent surgical excision of the mass, which was later diagnosed as a malignant PT pathology. After the surgery, the patient was monitored through regular follow-up visits, during which all examinations were normal. However, six months later, a new mass was felt in the same area. She underwent another surgical excision, and this mass was diagnosed as a benign PT. Conclusion: Malignant PTs should be taken into account for patients who present with rapidly growing breast masses. Timely diagnosis and treatment are vital because they significantly affect the prognosis of these cases. A thorough evaluation, including ultrasound and biopsy, is necessary to prevent misdiagnosis. The definitive diagnosis of PTs can only be established through biopsy. Effective treatment, which involves surgical excision with clear margins, is crucial for preventing recurrence and potentially life-threatening consequences.Objective: Phyllodes tumors (PTs) are rare, distinctive fibroepithelial neoplasms. They are associated with a low incidence and comprise 0.3% - 0.9% of all breast tumors. Recurrence occurs in about 20% of cases, and malignant PTs exhibit a higher rate of early recurrence than benign ones. The transformation from malignant to benign PTs is extremely rare. Here, we presented the case of a 29-year-old woman diagnosed with a malignant PT that transformed into a benign Within six months after excisional surgery. Materials and Methods: This is a case report. Results: A 29-year-old woman presented to our hospital with left breast enlargement, which was not accompanied by pain or discharge. An ultrasound revealed a heterogeneous, solid mass. She underwent surgical excision of the mass, which was later diagnosed as a malignant PT pathology. After the surgery, the patient was monitored through regular follow-up visits, during which all examinations were normal. However, six months later, a new mass was felt in the same area. She underwent another surgical excision, and this mass was diagnosed as a benign PT. Conclusion: Malignant PTs should be taken into account for patients who present with rapidly growing breast masses. Timely diagnosis and treatment are vital because they significantly affect the prognosis of these cases. A thorough evaluation, including ultrasound and biopsy, is necessary to prevent misdiagnosis. The definitive diagnosis of PTs can only be established through biopsy. Effective treatment, which involves surgical excision with clear margins, is crucial for preventing recurrence and potentially life-threatening consequences.

关 键 词：Phyllodes Tumor of the Breast Breast Neoplasms Neoplasm Recurrence LOCAL 

分 类 号：R73[医药卫生—肿瘤]