Antioxidant and Immunopotentiating Effects of <i>Cordyceps </i>Mycelium Extract, Chicken Essence, and Their Combination in Experimental Models  

作　　者：Hoi Yan Leung Choly Tat Ming Yan Kam Ming Ko Hoi Yan Leung;Choly Tat Ming Yan;Kam Ming Ko(Division of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR, China;Royal Medic Group Holding Limited, Hong Kong SAR, China)

机构地区：[1]Division of Life Science, Hong Kong University of Science & Technology, Hong Kong SAR, China [2]Royal Medic Group Holding Limited, Hong Kong SAR, China

出　　处：《Chinese Medicine》2021年第1期1-9,共9页中医（英文）

摘　　要：<i><span style="font-family:Verdana;">Cordyceps</span></i><span style="font-family:Verdana;"> mycelium extract (Cs-4), Chicken Essence (CE), and their combination were investigated for antioxidant and immunomodulatory activities in mouse models. Long-term treatment with Cs-4 or CE at equivalent human doses improved antioxidant status in various tissues, as evidenced by the enhancement of mitochondrial glutathione redox status in the brain, liver, heart, and kidney of mice. Cs-4 or CE treatment also produced an immunomodulatory action, as indicated by the potentiation of Concanavalin A-/lipopolysaccharide-induced proliferation of mouse splenocytes <i></i></span><i><i><span style="font-family:Verdana;">ex vivo</span></i><span style="font-family:Verdana;"></span></i>. While doubling of the equivalent human doses of Cs-4 and CE did not further enhance their antioxidant or immunopotentiating effects, the combined treatment with Cs-4 and CE at their respective equivalent human doses produced an additive effect, with the extents of stimulation being larger than those produced by Cs-4 or CE alone. The results have demonstrated for the first time that the combined use of Cs-4 and CE can produce an additive effect on both antioxidation and immunopotentiation that cannot otherwise be achieved by increasing the equivalent human doses of Cs-4 or CE alone.<i><span style="font-family:Verdana;">Cordyceps</span></i><span style="font-family:Verdana;"> mycelium extract (Cs-4), Chicken Essence (CE), and their combination were investigated for antioxidant and immunomodulatory activities in mouse models. Long-term treatment with Cs-4 or CE at equivalent human doses improved antioxidant status in various tissues, as evidenced by the enhancement of mitochondrial glutathione redox status in the brain, liver, heart, and kidney of mice. Cs-4 or CE treatment also produced an immunomodulatory action, as indicated by the potentiation of Concanavalin A-/lipopolysaccharide-induced proliferation of mouse splenocytes <i></i></span><i><i><span style="font-family:Verdana;">ex vivo</span></i><span style="font-family:Verdana;"></span></i>. While doubling of the equivalent human doses of Cs-4 and CE did not further enhance their antioxidant or immunopotentiating effects, the combined treatment with Cs-4 and CE at their respective equivalent human doses produced an additive effect, with the extents of stimulation being larger than those produced by Cs-4 or CE alone. The results have demonstrated for the first time that the combined use of Cs-4 and CE can produce an additive effect on both antioxidation and immunopotentiation that cannot otherwise be achieved by increasing the equivalent human doses of Cs-4 or CE alone.

关 键 词：Cordyceps Chicken Essence Glutathione Redox Status IMMUNOPOTENTIATION Additive Effect 

分 类 号：R73[医药卫生—肿瘤]