Comparative study of breast cancer in Mexican and Mexican-American women  

作　　者：Maria Elena Martinez Luis Enrique Gutierrez-Millan Melissa Bondy Adrian Daneri-Navarro Maria Mercedes Meza-Montenegro Ivan Anduro-Corona Ma Isabel Aramburo-Rubio Luz Maria Adriana Balderas-Pena Jose Adelfo Barragan-Ruiz Abenaa Brewster Graciela Caire-Juvera Juan Manuel Castro-Cervantes Mario Alberto Chavez Zamudio Giovanna Cruz Alicia Del Toro-Arreola Mary EEdgerton Maria Rosa Flores-Marquez Ramon Antonio Franco-Topete Helga Garcia Susan Andrea Gutierrez-Rubio Karin Hahn Luz Margarita Jimenez-Perez Ian KKomenaka Zoila Areli Lopez Bujanda Dihui Lu Gilberto Morgan-Villela James LMurray Jesse NNodora Antonio Oceguera-Villanueva Miguel Angel Ortiz Martinez Laura Perez Michel Antonio Quintero-Ramos Aysegul Sahin Jeong Yun Shim Maureen Stewart Gonzalo Vazquez-Camacho Betsy Wertheim Rachel Zenuk Patricia Thompson 

机构地区：[1]Arizona Cancer Center and Mel and Enid Zuckerman College of Public Health,University of Arizona,Tucson,USA [2]Departamento de Investigaciones Cientificas y Tecnologicas,Universidad de Sonora,Hermosillo,Mexico [3]University of Texas M.D.Anderson Cancer Center,Houston,USA [4]Departamento de Fisiologia,Centro Universitario de Ciencias de la Salud,Universidad de Guadalajara,Guadalajara,Mexico [5]Instituto Tecnologico de Sonora,Ciudad Obregón,Mexico [6]Instituto Mexicano del Seguro Social,Hermosillo,Mexico [7]Instituto Mexicano del Seguro Social,CMNO,Guadalajara,Jalisco [8]Centro de Investigacion en Alimentacion y Desarrollo,Hermosillo,Mexico [9]Instituto Mexicano del Seguro Social,Ciudad Obregon,Mexico [10]OPD Hospital Civil de Guadalajara,Guadalajara,Mexico [11]Departamento de Salud Publica,Centro Universitario de Ciencias de la Salud,Universidad de Guadalajara,Guadalajara,Mexico [12]Maricopa Medical Center,Department of Surgery,Phoenix,USA [13]University of North Carolina,Lineberger Cancer Center,Chapel Hill,USA [14]Arizona Cancer Center and Department of Family and Community Medicine,University of Arizona,Tucson,USA [15]Instituto Jalisciense de Cancerologia,Guadalajara,Mexico

出　　处：《Health》2010年第9期1040-1048,共9页健康（英文）

摘　　要：Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.Breast cancer is the number one cause of can- cer deaths among Hispanic women in the United States, and in Mexico, it recently became the primary cause of cancer deaths. This malign- nancy represents a poorly understood and un- derstudied disease in Hispanic women. The ELLA Binational Breast Cancer Study was es- tablished in 2006 as a multi-center study to as- sess patterns of breast tumor markers, clinical characteristics, and their risk factors in women of Mexican descent. We describe the design and implementation of the ELLA Study and provide a risk factor comparison between women in the U.S. and those in Mexico based on a sample of 765 patients (364 in the U.S. and 401 in Mexico). Compared to women in Mexico, U.S. women had significantly (p < 0.05) lower parity (3.2 vs. 3.9 mean live births) and breastfeeding rates (57.5% vs. 80.5%), higher use of oral contraceptives (60.7% vs. 50.1%) and hormone replacement therapy (23.3% vs. 7.6%), and higher family history of breast cancer (15.7% vs. 9.0%). Re- sults show that differences in breast cancer risk factor patterns exist between Mexico and U.S. women. We provide lessons learned from the conduct of our study. Binational studies are an important step in understanding disease pat- terns and etiology for women in both countries.

关 键 词：Binational Study Breast Cancer Hispanics Mexico United States 

分 类 号：R73[医药卫生—肿瘤]