Effects of methanolic extract of <i>Pausinystalia yohimbe</i>bark on blood glucose level in normal fasting rats  

作　　者：Hozeifa Mohamed Hassan Taj Eldin Imad Mohamed Elhadi Mohamed Mohamed Ahmed Abd Elwahab Hassan Mohamed Nizar Sirag 

机构地区：[1]Department of Pharmacognosy, Faculty of Pharmacy, University of Gezira, Wad Medani, Sudan [2]Department of Pharmacology and Toxicology, Medicinal and Aromatic Plant Research Institute, National Centre of Research, Khartoum, Sudan [3]Department of Pharmacology, Faculty of Pharmacy, University of Gezira, Wad Medani, Sudan

出　　处：《Health》2012年第12期1225-1228,共4页健康（英文）

摘　　要：Background: Pausinystalia yohimbe (L.) is a member of the family Rubiaceae. It is a valuable medicinal tree, distributed in evergreen closed-canopy forests in West Africa. It is traditionally used for treatment of erectile dysfunction and diabetes. Objective: This was an attempt to evaluate the effects of methanolic extract of P. yohimbe bark on blood glucose level in normal fasting rats. Methods: Different doses of methanolic extract of P. yohimbe bark (5, 10, 20, 40 and 80 mg/kg/mL) were orally administered to normal fasting rats to assess their effects on blood glucose levels. Results: The methanolic extract of P. yohimbe bark in different concentrations (5, 10, 20, 40 and 80 mg/kg/mL) when administered to normal fasting rats, only a considerable reduction (26.57 mg/dL) was produced by the dose of 20 mg/kg/mL. Conclusion and Recommendation: Although P. yohimbe has long been reported to regulate blood glucose levels;such effect is unclear and remains requiring further studies.Background: Pausinystalia yohimbe (L.) is a member of the family Rubiaceae. It is a valuable medicinal tree, distributed in evergreen closed-canopy forests in West Africa. It is traditionally used for treatment of erectile dysfunction and diabetes. Objective: This was an attempt to evaluate the effects of methanolic extract of P. yohimbe bark on blood glucose level in normal fasting rats. Methods: Different doses of methanolic extract of P. yohimbe bark (5, 10, 20, 40 and 80 mg/kg/mL) were orally administered to normal fasting rats to assess their effects on blood glucose levels. Results: The methanolic extract of P. yohimbe bark in different concentrations (5, 10, 20, 40 and 80 mg/kg/mL) when administered to normal fasting rats, only a considerable reduction (26.57 mg/dL) was produced by the dose of 20 mg/kg/mL. Conclusion and Recommendation: Although P. yohimbe has long been reported to regulate blood glucose levels;such effect is unclear and remains requiring further studies.

关 键 词：Pausinystalia yohimbe BARK YOHIMBINE FASTING Blood Glucose Level HYPOGLYCEMIA 

分 类 号：R5[医药卫生—内科学]