Helicobacter Increase Instability Genome in Mucous Cells of Antrum of Stomach Mucous in People, Who Lives in Radiation Contaminated Areas  

作　　者：Sergey Lopatin Viacheslav Kravtsov Sergey Dudarenko Vera Ellinidi 

机构地区：[1]The Nikiforov Russian Center of Emergency and Radiation Medicine EMERCOM, Saint-Petersburg, Russia [2]Pushkin Leningrad State University, Saint-Petersburg, Russia

出　　处：《Health》2015年第3期413-418,共6页健康（英文）

摘　　要：The research of degree of incidence of genomic changes (of micronuclei) in mucous cells of gastric superficial-foveolar epithelium in contaminated and not contaminated mucous of stomach was made. Histopathological research of micronuclei and helicobacter was made in gastric biopsy specimen of patients with diagnosis-chronical gastritis (ICD-10K29.3) in group of patients who lived in radiation contaminated areas and in groups of people, who had no factors of radiation influence in anamnesis. People, who lived in the radiation contaminated areas, whose mucous was infected by Helicobacter pylori, had the highest frequency of mucous cells with micronuclei. In the group of patients from radiation contaminated areas with HP-associated gastritis frequency of appearance of mucous cells with micronucleus in the mucous of stomach have five time more, than patients, whose mucous of stomach was not infected (p Helicobacter pylori can success in mutagenic effect of radiation factor.The research of degree of incidence of genomic changes (of micronuclei) in mucous cells of gastric superficial-foveolar epithelium in contaminated and not contaminated mucous of stomach was made. Histopathological research of micronuclei and helicobacter was made in gastric biopsy specimen of patients with diagnosis-chronical gastritis (ICD-10K29.3) in group of patients who lived in radiation contaminated areas and in groups of people, who had no factors of radiation influence in anamnesis. People, who lived in the radiation contaminated areas, whose mucous was infected by Helicobacter pylori, had the highest frequency of mucous cells with micronuclei. In the group of patients from radiation contaminated areas with HP-associated gastritis frequency of appearance of mucous cells with micronucleus in the mucous of stomach have five time more, than patients, whose mucous of stomach was not infected (p Helicobacter pylori can success in mutagenic effect of radiation factor.

关 键 词：HELICOBACTER PYLORI Immunohistochemistry Micronuclei Mucous Cells of the Stomach CHERNOBYL Accident 

分 类 号：R73[医药卫生—肿瘤]