The Level of CD4⁺T Cell Count among Reproductive Age Women Coinfected with Human Immune Virus, Hepatitis Surface Antigen and Herpes Simplex Virus in Kogi State, Nigeria  

作　　者：Babatunde Ishola Gabriel Adejumo Francis Enifo Oronsaye Uteno Itanyi Drisu Margaret Oyarazi Adebowale Ojo Moses Oke Uchechukwu Dimkpa Kingsley Ifeanyichukwu Omosor Oladimeji Nasiru Abdulrahman Esmond Nwanbunneze Ukatu Emmanuel Alaba Michael 

机构地区：[1]Medical Laboratory Science Department, University of Benin, Benin City, Nigeria [2]Department of Medical Services, Federal Polytechnic, Idah, Nigeria [3]Medical Laboratory Science Department, Federal School of Medical Laboratory Sciences and Health Technology, Jos, Nigeria [4]Medical Laboratory Science Department, School of Health Sciences and Technology, Akure, Nigeria [5]Physiology Department, Nnewi Campus, Nnamdi Azikiwe University, Awka, Nigeria [6]Shalom Diagnostic Medical Laboratory, Warri, Nigeria [7]Medical Laboratory Science Department, College of Health Technology, Offa, Nigeria [8]Gulin Pharmaceuticals Nigeria Limited, Sango Ottaa, Nigeria [9]Medical Laboratory Science Department, College of Health Sciences and Technology, Idah, Nigeria

出　　处：《Health》2018年第10期1449-1458,共10页健康（英文）

摘　　要：Background: There are pockets of evidence to show the existence of co-infections of viral particles in humans. Aim: The study aimed at evaluating the CD4+ T cell count among women of reproductive age co-infected with human immune virus, hepatitis surface antigen and herpes simplex virusin Kogi state, Nigeria. Methodology: 342 females of reproductive age within the ages of 15 - 49 years participated in this study. They were recruited from various local government areas of three Senatorial districts of Kogi state. Blood samples were collected from participants and analyzed for HSV1/HSV2, HIV, HBsAg and CD4 using different scientific methods and procedures. Results: There was no significant differences in mean CD4+ T cell counts between subjects who tested positive and those who tested negative for only HSV1 (p = 0.61), HSV2 (p = 0.95), HIV (p = 0.48) and co-infection for HSV1, HSV2, HIV (0.68). In contrast, mean CD4+ T cell count was significantly higher in those who tested positive compared with those who tested negative for HBsAg alone (p = 0.03) and those co-infected with HSV1, HSV2, HBsAg (p = 0.01). Analysis of variance (ANOVA) indicated no significant differences in CD4+ T cell counts among the different classes of infections. Conclusion: This study shows no decline in the count of CD4+ T cell on the co-infections of HSV1, HSV2 and HIV, but higher significant difference in those co-infected with HSV1, HSV2 and HBsAg was recorded among the women of child bearing age in Kogi state.Background: There are pockets of evidence to show the existence of co-infections of viral particles in humans. Aim: The study aimed at evaluating the CD4+ T cell count among women of reproductive age co-infected with human immune virus, hepatitis surface antigen and herpes simplex virusin Kogi state, Nigeria. Methodology: 342 females of reproductive age within the ages of 15 - 49 years participated in this study. They were recruited from various local government areas of three Senatorial districts of Kogi state. Blood samples were collected from participants and analyzed for HSV1/HSV2, HIV, HBsAg and CD4 using different scientific methods and procedures. Results: There was no significant differences in mean CD4+ T cell counts between subjects who tested positive and those who tested negative for only HSV1 (p = 0.61), HSV2 (p = 0.95), HIV (p = 0.48) and co-infection for HSV1, HSV2, HIV (0.68). In contrast, mean CD4+ T cell count was significantly higher in those who tested positive compared with those who tested negative for HBsAg alone (p = 0.03) and those co-infected with HSV1, HSV2, HBsAg (p = 0.01). Analysis of variance (ANOVA) indicated no significant differences in CD4+ T cell counts among the different classes of infections. Conclusion: This study shows no decline in the count of CD4+ T cell on the co-infections of HSV1, HSV2 and HIV, but higher significant difference in those co-infected with HSV1, HSV2 and HBsAg was recorded among the women of child bearing age in Kogi state.

关 键 词：HSV1/HSV2 CD4 HIV HBsAg Coinfections WOMEN Kogi STATE NIGERIA 

分 类 号：R73[医药卫生—肿瘤]