Uniphyline-Induced Hypophosphatemia: A Rare Etiology of Severe Respiratory Failure  

作　　者：Hassan Mohammed Ismael Mohammed Farooq Ahmad Mohamed Abdalrahman Ghazy Mohamed Hassan Mohammed Ismael Mohammed;Farooq Ahmad;Mohamed Abdalrahman;Ghazy Mohamed(Gastroenterology/Medicine Department, United Lincolnshire Hospitals NHS Trust, Grantham Hospital, Grantham, UK;Diabetes and Endocrinology Department, United Lincolnshire Hospitals NHS Trust, Grantham Hospital, Grantham, UK;Acute Medicine Department, United Lincolnshire Hospitals NHS Trust, Grantham Hospital, Grantham, UK;University Hospital Coventry NHS Trust, Coventry, UK)

机构地区：[1]Gastroenterology/Medicine Department, United Lincolnshire Hospitals NHS Trust, Grantham Hospital, Grantham, UK [2]Diabetes and Endocrinology Department, United Lincolnshire Hospitals NHS Trust, Grantham Hospital, Grantham, UK [3]Acute Medicine Department, United Lincolnshire Hospitals NHS Trust, Grantham Hospital, Grantham, UK [4]University Hospital Coventry NHS Trust, Coventry, UK

出　　处：《Health》2023年第7期810-813,共4页健康（英文）

摘　　要：Hypophosphataemia is defined as low level of phosphate in the blood (normal range 0.8 - 1.4 mmol/l), which can be drug-induced such as uniphyline. We present a case of elderly female patient with known chronic obstructive pulmonary disease, admitted with acute respiratory failure and low serum phosphate level, her clinical signs and serum phosphate level did not improve with conventional therapy and intravenous phosphate replacement, until her recently commenced uniphyline was discontinued. This highlights the importance of awareness amongst the clinicians about this rare but potential side effect of uniphyline. We suggest monitoring phosphate levels in patients admitted with acute respiratory failure especially those on extended bronchodilator therapy.Hypophosphataemia is defined as low level of phosphate in the blood (normal range 0.8 - 1.4 mmol/l), which can be drug-induced such as uniphyline. We present a case of elderly female patient with known chronic obstructive pulmonary disease, admitted with acute respiratory failure and low serum phosphate level, her clinical signs and serum phosphate level did not improve with conventional therapy and intravenous phosphate replacement, until her recently commenced uniphyline was discontinued. This highlights the importance of awareness amongst the clinicians about this rare but potential side effect of uniphyline. We suggest monitoring phosphate levels in patients admitted with acute respiratory failure especially those on extended bronchodilator therapy.

关 键 词：HYPOPHOSPHATEMIA Acute Respiratory Failure Chronic Obstructive Pulmonary Disease Uniphyline Theophyline Bronchodilator Therapy 

分 类 号：R73[医药卫生—肿瘤]