Episodic Learning and Memory in Prodromal Huntington’s Disease: The Role of Multimodal Encoding and Selective Reminding  

作　　者：Tarja-Brita Robins Wahlin Ake Wahlin Gerard JByrne 

机构地区：[1]Department of Neurobiology,Care Sciences and Society,Karolinska Institute,Stockholm,Sweden [2]School of Medicine,The University of Queensland,Brisbane,Australia [3]School of Health and Welfare,Jonkoping University,Jonkoping,Sweden

出　　处：《International Journal of Clinical Medicine》2015年第11期876-886,共11页临床医学国际期刊（英文）

基　　金：Department of Clinical Genetics, Karolinska University Hospital

摘　　要：This study investigated episodic memory in prodromal HD. Three groups were compared (N = 70): mutation carriers with less than 12.5 years to disease onset (n = 16), mutation carriers with 12.5 or more years to disease onset (n = 16), and noncarriers (n = 38). Episodic memory was assessed using the Fuld Object Memory Evaluation, which included multimodal presentation and selective reminding, and the Claeson-Dahl Learning Test which included verbal repeated presentation and recall trials. Both carrier groups demonstrated deficient episodic memory compared to noncarriers. The results suggest deficient episodic memory in prodromal HD, and that inconsistent retrieval contributes to these deficits. Multimodal presentation attenuates the deficits.This study investigated episodic memory in prodromal HD. Three groups were compared (N = 70): mutation carriers with less than 12.5 years to disease onset (n = 16), mutation carriers with 12.5 or more years to disease onset (n = 16), and noncarriers (n = 38). Episodic memory was assessed using the Fuld Object Memory Evaluation, which included multimodal presentation and selective reminding, and the Claeson-Dahl Learning Test which included verbal repeated presentation and recall trials. Both carrier groups demonstrated deficient episodic memory compared to noncarriers. The results suggest deficient episodic memory in prodromal HD, and that inconsistent retrieval contributes to these deficits. Multimodal presentation attenuates the deficits.

关 键 词：Prodromal Huntington’s Disease Fuld Object Memory Evaluation Episodic Memory Short-Term Memory Neurodegenerative Diseases 

分 类 号：R73[医药卫生—肿瘤]