Three Dimensional Expansion of Margins for Single-fraction Treatments: Stereotactic Radiosurgery Brain Cases  

作　　者：Qinghui Zhang Maria Chan Yulin Song Chandra Burman 

机构地区：[1]Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065

出　　处：《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》2012年第2期15-22,共8页医学物理学、临床工程、放射肿瘤学（英文）

摘　　要：Purpose: To derive a clinically-practical margin formula between clinical target volume (CTV) and planning target volume (PTV) for single-fraction stereotactic radiosurgery (SRS). Methods: In previous publications on the margin between the CTV and the PTV, a Gaussian function with zero mean was assumed for the systematic error and the machine systematic error was completely ignored. In this work we adopted a Dirac delta function for the machine systematic error for a given machine with nonzero mean systematic error. Mathematical formulas for calculating the CTV-PTV margin for single-fraction SRS treatments were proposed. Results: Margins for single fraction treatments were derived such that the CTVs received the prescribed dose in 95% of the SRS patients. The margin defined in this study was machine specific and accounted for nonzero mean systematic error. The differences between our formulas and a previously published formula were discussed. Conclusion: Clinical margin formulas were proposed for determining the margin between the CTV and the PTV in SRS treatments. Previous margin’s recipes, being derived specifically for conventional treatments, may be inappropriate for single-fraction SRS and could result in geometric miss of the target and even treatment failure for machines possessing of large systematic errors.Purpose: To derive a clinically-practical margin formula between clinical target volume (CTV) and planning target volume (PTV) for single-fraction stereotactic radiosurgery (SRS). Methods: In previous publications on the margin between the CTV and the PTV, a Gaussian function with zero mean was assumed for the systematic error and the machine systematic error was completely ignored. In this work we adopted a Dirac delta function for the machine systematic error for a given machine with nonzero mean systematic error. Mathematical formulas for calculating the CTV-PTV margin for single-fraction SRS treatments were proposed. Results: Margins for single fraction treatments were derived such that the CTVs received the prescribed dose in 95% of the SRS patients. The margin defined in this study was machine specific and accounted for nonzero mean systematic error. The differences between our formulas and a previously published formula were discussed. Conclusion: Clinical margin formulas were proposed for determining the margin between the CTV and the PTV in SRS treatments. Previous margin’s recipes, being derived specifically for conventional treatments, may be inappropriate for single-fraction SRS and could result in geometric miss of the target and even treatment failure for machines possessing of large systematic errors.

关 键 词：Margin CONE-BEAM CT IMAGE-GUIDED Radiation Treatment RADIOSURGERY BRAIN tumor 

分 类 号：R73[医药卫生—肿瘤]