A Novel Technique to Validate Dosimetry for Single-Isocenter Multiple-Target VMAT Stereotactic Radiosurgery  

作　　者：Yulin Song Miao Zhang Laszlo Voros Xiaoli Tang Ziad Saleh Weixing Cai Jeho Jeong Boris Mueller Borys Mychalczak Yulin Song;Miao Zhang;Laszlo Voros;Xiaoli Tang;Ziad Saleh;Weixing Cai;Jeho Jeong;Boris Mueller;Borys Mychalczak(Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA;Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA)

机构地区：[1]Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, USA [2]Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, USA

出　　处：《International Journal of Medical Physics, Clinical Engineering and Radiation Oncology》2021年第2期59-68,共10页医学物理学、临床工程、放射肿瘤学（英文）

摘　　要：<div style="text-align:justify;"> Each year, 170,000 cancer patients in the United States develop brain metastases. Many of them present with multiple small lesions. Historically, Linac-based stereotactic radiosurgery (SRS) was used to treat single solitary brain metastasis with a diameter of less than 3.0 cm, while whole brain radiation therapy (WBRT) was used to treat multiple brain metastases mainly as palliative therapy. Evidence-based practices reveal that WBRT results in poor treatment outcomes, with high local recurrence rates, decreased cognitive function, and even the onset of dementia. Recently, volumetric modulated arc therapy (VMAT) SRS has been tested as an alternative treatment to WBRT. Owing to its inherent complexity and high risk, it is imperative to perform rigorous testing prior to its clinical implementation. In this paper, we present a novel technique for dosimetry validation of VMAT SRS. </div><div style="text-align:justify;"> Each year, 170,000 cancer patients in the United States develop brain metastases. Many of them present with multiple small lesions. Historically, Linac-based stereotactic radiosurgery (SRS) was used to treat single solitary brain metastasis with a diameter of less than 3.0 cm, while whole brain radiation therapy (WBRT) was used to treat multiple brain metastases mainly as palliative therapy. Evidence-based practices reveal that WBRT results in poor treatment outcomes, with high local recurrence rates, decreased cognitive function, and even the onset of dementia. Recently, volumetric modulated arc therapy (VMAT) SRS has been tested as an alternative treatment to WBRT. Owing to its inherent complexity and high risk, it is imperative to perform rigorous testing prior to its clinical implementation. In this paper, we present a novel technique for dosimetry validation of VMAT SRS. </div>

关 键 词：Brain Metastasis VMAT SRS WBRT Film Dosimetry 

分 类 号：R73[医药卫生—肿瘤]