The Selective Serotonin Reuptake Inhibitor-Sertraline Diminishes Conspecific Aggression in Male Fighting <i>Betta splendens</i>Fish  

作　　者：Bogdam Feliks Kania Danuta Wrońska 

机构地区：[1]University Veterinary Medicine Center JU-AU, Faculty of Animal Sciences, Hugon Kollataj Agricultural University, Cracow, Poland [2]Department of Animal Physiology and Endocrinology, Faculty of Animal Sciences, Hugon Kollataj Agricultural University, Cracow, Poland

出　　处：《Journal of Behavioral and Brain Science》2015年第13期578-585,共8页行为与脑科学期刊（英文）

摘　　要：In conspecific type of aggression the modulation of 5-hydroxytryptamine (5-HT) plays a main role. A decrease of 5-HT in the brain intensifies this type of aggression and in contrast, the increase of 5-HT reduces it. The aim of this study was to examine the effects of different concentrations of sertraline HCl on aggressive behavior of Betta splendens male fish. It was concluded that sertraline added to aquarium water in the dose of 0.4, 4.0 and/or 100.0 μg·L-1 BW during 14 days of exposition increased synaptic levels of 5-HT which in turn resulted in reduction of specific aggressive behavior in the environmental concentrations (0.4 μg) and then times higher. Sertraline caused a periodic, and sometimes even total weakening of the male-male type fight, which was a standard trial applied in ethological research on the Siamese fighting fish. In the current study, the most effective one is proved to be the dose of 4.0 μg·L-1 BW (parallel to earlier investigated fluoxetine in the same dose).In conspecific type of aggression the modulation of 5-hydroxytryptamine (5-HT) plays a main role. A decrease of 5-HT in the brain intensifies this type of aggression and in contrast, the increase of 5-HT reduces it. The aim of this study was to examine the effects of different concentrations of sertraline HCl on aggressive behavior of Betta splendens male fish. It was concluded that sertraline added to aquarium water in the dose of 0.4, 4.0 and/or 100.0 μg·L-1 BW during 14 days of exposition increased synaptic levels of 5-HT which in turn resulted in reduction of specific aggressive behavior in the environmental concentrations (0.4 μg) and then times higher. Sertraline caused a periodic, and sometimes even total weakening of the male-male type fight, which was a standard trial applied in ethological research on the Siamese fighting fish. In the current study, the most effective one is proved to be the dose of 4.0 μg·L-1 BW (parallel to earlier investigated fluoxetine in the same dose).

关 键 词：AGGRESSION FISH Serotonin REUPTAKE Inhibitor 

分 类 号：R73[医药卫生—肿瘤]