Analysis on Correlation between Resistin—420C/G Polymorphism and Type 2 Diabetes Mellitus Macroangiopathy in Han Population of Northeast China  

作　　者：Bingxue Qi Ma Yan Yadong Sun 

机构地区：[1]Department of Endocrinology, People’s Hospital of Jilin Province, Changchun, China

出　　处：《Journal of Biosciences and Medicines》2017年第12期17-23,共7页生物科学与医学（英文）

摘　　要：Objective: To study the allelic and genotypic frequency distribution of RETN—420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods: The genotypes and their frequencies of a total of 180 cases, including 60 cases of T2DM complicated with macroangiopathy, 60 cases of simple T2DM and 60 cases of normal control (ND), were measured by PCR—RFLP. Results: The allelic frequencies and simple CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group (P Conclusion: The RETN—420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.Objective: To study the allelic and genotypic frequency distribution of RETN—420C/G single nucleotide polymorphisms (SNPs) and its relationship with type 2 diabetes mellitus (T2DM) complicated with macroangiopathy in Han population of northeast China. Methods: The genotypes and their frequencies of a total of 180 cases, including 60 cases of T2DM complicated with macroangiopathy, 60 cases of simple T2DM and 60 cases of normal control (ND), were measured by PCR—RFLP. Results: The allelic frequencies and simple CC/GC + GG genotype in T2DM complicated with macroangiopathy group were significant different compared with ND group (P Conclusion: The RETN—420C/G polymorphism has a correlation with the occurrence of T2DM complicated with macroangiopathy in Han population of northeast China.

关 键 词：Type 2 Diabetes MELLITUS RESISTIN Gene POLYMORPHISM MACROANGIOPATHY POLYMERASE Chain Reaction 

分 类 号：R5[医药卫生—内科学]