Presence of G84E Allelic Heterogeneity of the European Prostate Cancer SNP Mutation of HOX13B-G84E Associated with the European R-Haplogroup of Y-Chromosome and Absence of Gene Flow into Moroccans Patients  

作　　者：Ihsan Ali Mahasneh Moulay Mustapha Ennaji Berjas Abumsimir Yassine Kasmi Ihsan Ali Mahasneh;Moulay Mustapha Ennaji;Berjas Abumsimir;Yassine Kasmi(Department of Biotechnology, Faculty of Science, University of Sharjah, Sharjah, UAE;Team of Virology, Oncology, and Medical Biotechnologies;Laboratory of Virology, Microbiology, Quality, and Biotechnologies/ ETB;Faculty of Sciences and Techniques, Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco)

机构地区：[1]Department of Biotechnology, Faculty of Science, University of Sharjah, Sharjah, UAE [2]Team of Virology, Oncology, and Medical Biotechnologies Laboratory of Virology, Microbiology, Quality, and Biotechnologies/ ETB Faculty of Sciences and Techniques, Mohammedia, Hassan II University of Casablanca, Casablanca, Morocco

出　　处：《Journal of Biosciences and Medicines》2021年第5期50-61,共12页生物科学与医学（英文）

摘　　要：SNP mutations in the HOXB13 gene associated with prostate cancer were determined in Moroccans prostate cancer patients (PCa). All PCa SNP mutations were new and belong to the SNP point-mutations located on the stop codon of HOXB13 exon 1 and 2 located in chromosome 17. The five mutations and their frequencies were as follows: rs1197613952 (12%), rs1597934612 (4%), rs1597933874 (4%), rs1597933837 (4%) and rs867793282 (4%). The European HOXB13-G84E (rs138213197) PCa mutation was not detected among Moroccan patients. The Y-chromosome genealogical haplotypes of the Western European (R1b1b2-M2G9) and the Eastern European (R191a-M-17) were not observed in Moroccans PCa patients. The patients have their own haplotypes E1b1 and J with a frequency of 55 and 35%, respectively. The results of the SNP mutations in the HOXB13, the absence of the HOXB13-G84E of the European in the Moroccans PCa patients, the absence of the European-lineage haplogroups (R1a1a-M17 and R1b1b2-M269) and the presence of E1b1b and J in Moroccans PCa patients would clearly indicate the absence of gene flow from European to Moroccans gene pool.SNP mutations in the HOXB13 gene associated with prostate cancer were determined in Moroccans prostate cancer patients (PCa). All PCa SNP mutations were new and belong to the SNP point-mutations located on the stop codon of HOXB13 exon 1 and 2 located in chromosome 17. The five mutations and their frequencies were as follows: rs1197613952 (12%), rs1597934612 (4%), rs1597933874 (4%), rs1597933837 (4%) and rs867793282 (4%). The European HOXB13-G84E (rs138213197) PCa mutation was not detected among Moroccan patients. The Y-chromosome genealogical haplotypes of the Western European (R1b1b2-M2G9) and the Eastern European (R191a-M-17) were not observed in Moroccans PCa patients. The patients have their own haplotypes E1b1 and J with a frequency of 55 and 35%, respectively. The results of the SNP mutations in the HOXB13, the absence of the HOXB13-G84E of the European in the Moroccans PCa patients, the absence of the European-lineage haplogroups (R1a1a-M17 and R1b1b2-M269) and the presence of E1b1b and J in Moroccans PCa patients would clearly indicate the absence of gene flow from European to Moroccans gene pool.

关 键 词：Prostate Cancer HOXB13 G84E Allelic Heterogeneity Y-Chromosome Haplogroups European Genome Moroccan Genome Gene Flow 

分 类 号：R73[医药卫生—肿瘤]