Effects of Ovariectomy and 17β-Estradiol Replacement on the Activity of Dopamine D2 Receptors in the Selection of Macronutrients Carbohydrates, Lipids and Proteins in Females Rats  

作　　者：Brahima Bamba Seydou Silué Tiémélé Eugène Atayi Antoine Némé Tako Brahima Bamba;Seydou Silué;Tiémélé Eugène Atayi;Antoine Némé Tako(Laboratoire de Neurosciences, UFR Biosciences, Université Félix Houphouë,t-Boigny, Abidjan, Cô,te d’Ivoire;Service de Neurologie, UFR Des Sciences Médicales, Centre Hospitalier et Universitaire (CHU) de Cocody, Abidjan, Cô,te d’Ivoire)

机构地区：[1]Laboratoire de Neurosciences, UFR Biosciences, Université Félix Houphouë,t-Boigny, Abidjan, Cô,te d’Ivoire [2]Service de Neurologie, UFR Des Sciences Médicales, Centre Hospitalier et Universitaire (CHU) de Cocody, Abidjan, Cô,te d’Ivoire

出　　处：《Journal of Biosciences and Medicines》2023年第5期76-110,共35页生物科学与医学（英文）

摘　　要：17β-estradiol modulates the activity of D2 receptors in the regulation of food intake and body weight. The functional lack of 17β-estradiol in postmenopausal women could create a dietary imbalance and cause body weight gain. This study aimed to better understand the interferences that could exist between 17β-estradiol, D2 receptors and the selection of carbohydrate, fat and protein consumption, as well as their consequences on body weight gain by using an animal model of the menopause. Ovariectomy exacerbates the consumption of foods rich in lipids. Thus confirming an inhibitory action of 17β-estradiol (E2) on the consumption of these types of foods. This consumption stimulates body weight gain, which is promoted by the high caloric content of these foods and not by the amount consumed. Our results showed a direct involvement of D2 receptors in food choice. This choice would be made according to the two (2) isoforms of the D2 receptors. The D2/BR isoform directs towards a high carbohydrate consumption, without causing a gain in body weight. While D2/SUL, promotes high fat food consumption, causing an increase in body weight. In women, 17β-estradiol modulates the activity ratio between these two D2 receptor isoforms to ensure energy and homeostatic balance, stabilizing food intake and body weight.17β-estradiol modulates the activity of D2 receptors in the regulation of food intake and body weight. The functional lack of 17β-estradiol in postmenopausal women could create a dietary imbalance and cause body weight gain. This study aimed to better understand the interferences that could exist between 17β-estradiol, D2 receptors and the selection of carbohydrate, fat and protein consumption, as well as their consequences on body weight gain by using an animal model of the menopause. Ovariectomy exacerbates the consumption of foods rich in lipids. Thus confirming an inhibitory action of 17β-estradiol (E2) on the consumption of these types of foods. This consumption stimulates body weight gain, which is promoted by the high caloric content of these foods and not by the amount consumed. Our results showed a direct involvement of D2 receptors in food choice. This choice would be made according to the two (2) isoforms of the D2 receptors. The D2/BR isoform directs towards a high carbohydrate consumption, without causing a gain in body weight. While D2/SUL, promotes high fat food consumption, causing an increase in body weight. In women, 17β-estradiol modulates the activity ratio between these two D2 receptor isoforms to ensure energy and homeostatic balance, stabilizing food intake and body weight.

关 键 词：17Β-ESTRADIOL D2 Receptors BROMOCRIPTINE SULPIRIDE Carbohydrates LIPIDS PROTEINS Body Weight Menopause Obesity 

分 类 号：F12[经济管理—世界经济]