Traditional Use, Phytochemistry, Pharmacological and Toxicological Properties of Acanthus ilicifolius: A Review  

作　　者：Fatema Tuz Zohora A. H. M. Nazmul Hasan K. M. Khairul Alam Tania Binte Wahed Fatema Tuz Zohora;A. H. M. Nazmul Hasan;K. M. Khairul Alam;Tania Binte Wahed(Department of Pharmacy, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka, Bangladesh;Department of Pharmacy, School of Medicine, University of Asia Pacific, Dhaka, Bangladesh)

机构地区：[1]Department of Pharmacy, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka, Bangladesh [2]Department of Pharmacy, School of Medicine, University of Asia Pacific, Dhaka, Bangladesh

出　　处：《Journal of Biosciences and Medicines》2023年第5期181-192,共12页生物科学与医学（英文）

摘　　要：The practice of plants for the deterrence and management of innumerable physiological states and diseases dates back to the history of humankind. Although many of today’s medicinal yields are achieved synthetically, they are often modelled on the chemical composition of medicinal plants. In this accordance, Acanthus genus (Family Acanthaceae) has acknowledged considerable attention due to its wide range of secondary metabolites and its customary usage in Indian and Chinese system of medicine. It is worth to mention that A. ilicifolius is enormously medicinal among all the species of Acanthus genus. This plant is considered to be rich sources of steroids, triterpenoids, saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for asthma, diabetes, dyspepsia, hepatitis, leprosy, neuralgia, paralysis, ringworm, skin disease, snake bite, leukemia. Toxicological investigation in mice model has showed that, the ethanolic extract of the leaves of this plant have no toxic effect up to dose of 1000 mg/kg BW, 2000 mg/kg BW dose have mild toxicity and 5000 mg/kg BW dose have caused toxic effect in some organ system like liver, heart, pancreas, lung and kidney. Different extract of this plant also exhibited Anti-inflammatory, anti-leishmanial, osteoblastic, hepatoprotective, antioxidant and anticancer activities. This review article is an endeavor to cover current expansion in phytochemical and pharmacological potential of this plant species which will be a good reference tool for investigators who wish to work on natural products.The practice of plants for the deterrence and management of innumerable physiological states and diseases dates back to the history of humankind. Although many of today’s medicinal yields are achieved synthetically, they are often modelled on the chemical composition of medicinal plants. In this accordance, Acanthus genus (Family Acanthaceae) has acknowledged considerable attention due to its wide range of secondary metabolites and its customary usage in Indian and Chinese system of medicine. It is worth to mention that A. ilicifolius is enormously medicinal among all the species of Acanthus genus. This plant is considered to be rich sources of steroids, triterpenoids, saponins, flavonoids, alkaloids, and tannins. Traditionally, the plant has been used for asthma, diabetes, dyspepsia, hepatitis, leprosy, neuralgia, paralysis, ringworm, skin disease, snake bite, leukemia. Toxicological investigation in mice model has showed that, the ethanolic extract of the leaves of this plant have no toxic effect up to dose of 1000 mg/kg BW, 2000 mg/kg BW dose have mild toxicity and 5000 mg/kg BW dose have caused toxic effect in some organ system like liver, heart, pancreas, lung and kidney. Different extract of this plant also exhibited Anti-inflammatory, anti-leishmanial, osteoblastic, hepatoprotective, antioxidant and anticancer activities. This review article is an endeavor to cover current expansion in phytochemical and pharmacological potential of this plant species which will be a good reference tool for investigators who wish to work on natural products.

关 键 词：Acanthus ACANTHACEAE Acanthus ilicifolius ANTI-CANCER Hepato-Protective Effect 

分 类 号：R75[医药卫生—皮肤病学与性病学]