Research Progress on MTHFR C677T and A1298C Gene Polymorphisms and Gastrointestinal Tumors  

作　　者：Yuwei Wang Lili Huo Zeyi Huang Xiaohui Shen Chenxue Jin Changqing Yang Yuwei Wang;Lili Huo;Zeyi Huang;Xiaohui Shen;Chenxue Jin;Changqing Yang(Department of Digestive Internal Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China)

机构地区：[1]Department of Digestive Internal Medicine, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China

出　　处：《Journal of Biosciences and Medicines》2023年第6期148-160,共13页生物科学与医学（英文）

摘　　要：Tumours of the digestive system include a number of malignant tumours such as oesophageal, gastric and colorectal cancers, which have the highest incidence and mortality rates in the world. Their occurrence is related to a variety of factors, such as diet, environment and genetics. As a key enzyme in the process of folate metabolism, MTHFR gene polymorphism plays an important role in the pathogenesis and development of gastrointestinal tumours. This paper provides a brief review of the relationship between MTHFR polymorphisms and digestive tumours, with a view to identifying the genetic effects of MTHFR, exploring the pathogenesis of digestive tract tumours and developing more effective prevention and treatment strategies.Tumours of the digestive system include a number of malignant tumours such as oesophageal, gastric and colorectal cancers, which have the highest incidence and mortality rates in the world. Their occurrence is related to a variety of factors, such as diet, environment and genetics. As a key enzyme in the process of folate metabolism, MTHFR gene polymorphism plays an important role in the pathogenesis and development of gastrointestinal tumours. This paper provides a brief review of the relationship between MTHFR polymorphisms and digestive tumours, with a view to identifying the genetic effects of MTHFR, exploring the pathogenesis of digestive tract tumours and developing more effective prevention and treatment strategies.

关 键 词：MTHFR POLYMORPHISM Esophageal Cancer Gastric Cancer Colorectal Cancer 

分 类 号：R73[医药卫生—肿瘤]