The Acute and Chronic Effects of Co-Administration of Turmeric and Black Pepper Extracts in Genetic Hypertension  

作　　者：Ma. Guadalupe Calderón-Gallardo Lilia Castillo-Martínez Samuel Estrada-Soto Itzell A. Gallardo-Ortíz Rafael Villalobos-Molina Ma. Guadalupe Calderón-Gallardo;Lilia Castillo-Martínez;Samuel Estrada-Soto;Itzell A. Gallardo-Ortíz;Rafael Villalobos-Molina(Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, México;Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Doctorado en Investigación Clínica Experimental en Salud, Universidad Nacional Autónoma de México, Ciudad de México, México;Instituto Nacional de Nutrición Salvador Zubirán, Ciudad de México, México;Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, México)

机构地区：[1]Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México, Tlalnepantla, México [2]Programa de Maestría y Doctorado en Ciencias Médicas, Odontológicas y de la Salud, Doctorado en Investigación Clínica Experimental en Salud, Universidad Nacional Autónoma de México, Ciudad de México, México [3]Instituto Nacional de Nutrición Salvador Zubirán, Ciudad de México, México [4]Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Cuernavaca, México

出　　处：《Journal of Biosciences and Medicines》2023年第8期114-128,共15页生物科学与医学（英文）

摘　　要：High blood pressure is the main risk factor for cardiovascular diseases, it affects many people worldwide and is a public health problem. This study explored the acute and chronic actions of a mixture of turmeric (95% curcumin) plus black pepper (95% piperine) extracts, in the blood pressure pattern in spontaneously hypertensive rats (SHR) along they age. For the acute study male adult (4 - 7 months old) SHR and their control Wistar Kyoto rats (WKY) were used. A single oral dose of the mixture of turmeric/black pepper extracts (200 mg/2mg, respectively) suspension was administered. Tail-cuff was used to determine blood pressure during 180 min. For the chronic study, young (1-month-old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In a second chronic assay adult (5 months old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In all three studies, a decrease in systolic, diastolic and mean blood pressure was observed, being higher in SHR and negligible in WKY rats. The mixture of turmeric/black pepper extracts showed antihypertensive actions in SHR rats with no effect on WKY rats. The mixture delayed the onset of hypertension in young SHR rats.High blood pressure is the main risk factor for cardiovascular diseases, it affects many people worldwide and is a public health problem. This study explored the acute and chronic actions of a mixture of turmeric (95% curcumin) plus black pepper (95% piperine) extracts, in the blood pressure pattern in spontaneously hypertensive rats (SHR) along they age. For the acute study male adult (4 - 7 months old) SHR and their control Wistar Kyoto rats (WKY) were used. A single oral dose of the mixture of turmeric/black pepper extracts (200 mg/2mg, respectively) suspension was administered. Tail-cuff was used to determine blood pressure during 180 min. For the chronic study, young (1-month-old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In a second chronic assay adult (5 months old) male SHR and their control WKY rats were fed with standard chow, or standard chow combined with cocoa, or combined with cocoa plus the mixture of turmeric/black pepper extracts;tail-cuff was used to determine blood pressure once a week, along 12 weeks. In all three studies, a decrease in systolic, diastolic and mean blood pressure was observed, being higher in SHR and negligible in WKY rats. The mixture of turmeric/black pepper extracts showed antihypertensive actions in SHR rats with no effect on WKY rats. The mixture delayed the onset of hypertension in young SHR rats.

关 键 词：Curcuma longa L. Peper nigrum L. HYPERTENSION POLYPHENOL SHR 

分 类 号：R54[医药卫生—心血管疾病]