Synergistic Mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera Aqueous Extract: Its Liver and Kidney Benefits in Male Albino Rat Model  

作　　者：Tamuno-Boma Odinga Cletus Barizoge Lemii Iyaeneomi Ransome Daka Christine U. Gabriel-Brisibe Sarah K. Enebeli Iyingiala Austin-Asomeji Felicia Ucheawaji Edward Tamuno-Boma Odinga;Cletus Barizoge Lemii;Iyaeneomi Ransome Daka;Christine U. Gabriel-Brisibe;Sarah K. Enebeli;Iyingiala Austin-Asomeji;Felicia Ucheawaji Edward(Department of Biochemistry, Faculty of Science, Rivers State University, Port Harcourt, Nigeria;Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Basic Medical Science, Rivers State University, Port Harcourt, Nigeria;Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Science, Rivers State University, Port Harcourt, Nigeria;Department of Community Medicine, Faculty of Clinical Sciences, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria)

机构地区：[1]Department of Biochemistry, Faculty of Science, Rivers State University, Port Harcourt, Nigeria [2]Department of Pharmacology and Therapeutics, Faculty of Basic Medical Sciences, College of Basic Medical Science, Rivers State University, Port Harcourt, Nigeria [3]Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medical Science, Rivers State University, Port Harcourt, Nigeria [4]Department of Community Medicine, Faculty of Clinical Sciences, College of Medical Sciences, Rivers State University, Port Harcourt, Nigeria

出　　处：《Journal of Biosciences and Medicines》2023年第10期63-75,共13页生物科学与医学（英文）

摘　　要：Background: The synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract is a common drink in Port Harcourt, Nigeria. It is assumed to have various health benefits. However, the synergistic mixture of the content has not been studied scientifically, hence the need to evaluate its effect on the liver and kidney being part of the body’s metabolic organs. Aim: This study evaluated the synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract in male albino rats. Methods: Acute toxicity LD₅₀ of STCD was carried out, afterwards, fifteen male albino rats were grouped into three groups with 5 rats in each group;Control, 200 mg/kg, 400 mg/kg STCD. The rats were administered STCD orally 24 hourly, for 21 days, with feed and water ad libitum. At the end of the experiment, blood samples were collected for biochemical analysis of the liver and kidney biomarkers, while the liver and kidney tissues were harvested for histopathological examination using standard laboratory methods. Descriptive statistics were computed and expressed as Mean ± SD. One-way ANOVA and Turkeys test was performed. P value ≤0.05 was considered statistically significant. Results: Acute toxicity LD50 of STCD was observed to be ≥2404.2 mg/kg body weight. An increase in the percentage body weight difference of 8.39% and 2.86% was observed for 200 and 400 mg/kg STCD groups. Also, the liver weight was observed to increase in 400 mg/kg (3.92 ± 1.42) in comparison to the control group (3.48 ± 1.61), a decrease in the kidney weight was observed in all groups administered STCD in comparison to the control group. Administration of STCD at both 200 and 400 mg/kg revealed a decrease in the concentration of the hepatic biomarkers AST, ALT, ALP, TP, Albumin, Total and conjugated bilirubin. The kidney biomarker Urea was observed to decrease in concentration for 200 mg/kg STCD (4.60 ± 1.83) and 400 mg/kg STCD (4.76 ± 0.74) when compared to the control grBackground: The synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract is a common drink in Port Harcourt, Nigeria. It is assumed to have various health benefits. However, the synergistic mixture of the content has not been studied scientifically, hence the need to evaluate its effect on the liver and kidney being part of the body’s metabolic organs. Aim: This study evaluated the synergistic mixture of Cyperus esculentus, Phoenix dactylifera and Cocos nucifera (STCD) aqueous extract in male albino rats. Methods: Acute toxicity LD₅₀ of STCD was carried out, afterwards, fifteen male albino rats were grouped into three groups with 5 rats in each group;Control, 200 mg/kg, 400 mg/kg STCD. The rats were administered STCD orally 24 hourly, for 21 days, with feed and water ad libitum. At the end of the experiment, blood samples were collected for biochemical analysis of the liver and kidney biomarkers, while the liver and kidney tissues were harvested for histopathological examination using standard laboratory methods. Descriptive statistics were computed and expressed as Mean ± SD. One-way ANOVA and Turkeys test was performed. P value ≤0.05 was considered statistically significant. Results: Acute toxicity LD50 of STCD was observed to be ≥2404.2 mg/kg body weight. An increase in the percentage body weight difference of 8.39% and 2.86% was observed for 200 and 400 mg/kg STCD groups. Also, the liver weight was observed to increase in 400 mg/kg (3.92 ± 1.42) in comparison to the control group (3.48 ± 1.61), a decrease in the kidney weight was observed in all groups administered STCD in comparison to the control group. Administration of STCD at both 200 and 400 mg/kg revealed a decrease in the concentration of the hepatic biomarkers AST, ALT, ALP, TP, Albumin, Total and conjugated bilirubin. The kidney biomarker Urea was observed to decrease in concentration for 200 mg/kg STCD (4.60 ± 1.83) and 400 mg/kg STCD (4.76 ± 0.74) when compared to the control gr

关 键 词：Cyperus esculentus (Tiger nuts) Phoenix dactylifera (Dates) and Cocos nucifera (Coconuts) LIVER KIDNEY Male Rats 

分 类 号：R69[医药卫生—泌尿科学]