Mesenchymal Stem Cell Allograft Improved Pain Management in Dogs with Osteoarthritis  

作　　者：Jonathan R. T. Lakey Wenyi Guo Michael Alexander Mike K. S. Chan Michelle B. F. Wong Todd Scott Jonathan R. T. Lakey;Wenyi Guo;Michael Alexander;Mike K. S. Chan;Michelle B. F. Wong;Todd Scott(Department of Surgery, University of California Irvine, Irvine, USA;Department of Biomedical Engineering, University of California Irvine, Irvine, USA;Department of Pancreatic Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China;European Wellness Biomedical Group, Edenkoben, Germany;Baden R&D Laboratories GmbH, Sabine Conrad Ferdinand-Laselle-Strasse, Edenkoben, Germany;Crestwood Veterinary Clinic, Edmonton, Canada)

机构地区：[1]Department of Surgery, University of California Irvine, Irvine, USA [2]Department of Biomedical Engineering, University of California Irvine, Irvine, USA [3]Department of Pancreatic Surgery, General Surgery, Qilu Hospital of Shandong University, Jinan, China [4]European Wellness Biomedical Group, Edenkoben, Germany [5]Baden R&D Laboratories GmbH, Sabine Conrad Ferdinand-Laselle-Strasse, Edenkoben, Germany [6]Crestwood Veterinary Clinic, Edmonton, Canada

出　　处：《Journal of Biosciences and Medicines》2023年第11期181-189,共9页生物科学与医学（英文）

摘　　要：Background: Osteoarthritis is one of the most common bone diseases, triggered by bone destruction stemming from the inflammatory response of chondrocytes. The disease progresses slowly, but halting its progression or finding a cure remains elusive. The treatment of pain associated with osteoarthritis has yielded unsatisfactory results. In recent years, mesenchymal stem cells (MSCs) have emerged as a potential avenue for addressing the condition. In this study, we used MSCs to treat companion dogs with osteoarthritis. Methods: For this study, 26 animals were included in this study to assess the pain and mobility one month after treatment. The pain scores were obtained from owners using a questionnaire based on the Helsinki Chronic Pain Index, and the Liverpool Osteoarthritis in Dogs (LOAD) Owner questionnaire to assess the mobility of the dogs from stem cell infusion. Results: Questionnaires were administered to dog owners before and one month after treatment, and we found that dogs treated with MSCS experienced an 81.2% ± 6.8% reduction in pain and a 77.9% ± 10.1% increase in mobility, whereas most of the dogs in the untreated control group experienced disease progression. Conclusions: The transplantation of stem cells into companion pets is a promising and expanding opportunity for pet owners with aging and arthritic dogs. MSCs may play an important role in the treatment of OA without complications in companion pets.Background: Osteoarthritis is one of the most common bone diseases, triggered by bone destruction stemming from the inflammatory response of chondrocytes. The disease progresses slowly, but halting its progression or finding a cure remains elusive. The treatment of pain associated with osteoarthritis has yielded unsatisfactory results. In recent years, mesenchymal stem cells (MSCs) have emerged as a potential avenue for addressing the condition. In this study, we used MSCs to treat companion dogs with osteoarthritis. Methods: For this study, 26 animals were included in this study to assess the pain and mobility one month after treatment. The pain scores were obtained from owners using a questionnaire based on the Helsinki Chronic Pain Index, and the Liverpool Osteoarthritis in Dogs (LOAD) Owner questionnaire to assess the mobility of the dogs from stem cell infusion. Results: Questionnaires were administered to dog owners before and one month after treatment, and we found that dogs treated with MSCS experienced an 81.2% ± 6.8% reduction in pain and a 77.9% ± 10.1% increase in mobility, whereas most of the dogs in the untreated control group experienced disease progression. Conclusions: The transplantation of stem cells into companion pets is a promising and expanding opportunity for pet owners with aging and arthritic dogs. MSCs may play an important role in the treatment of OA without complications in companion pets.

关 键 词：Stem Cell Therapy CANINE PAIN OSTEOARTHRITIS Mesenchymal Stem Cell 

分 类 号：R32[医药卫生—人体解剖和组织胚胎学]