Biological Profile and Cardiovascular Risk in Patients Receiving Neuroleptics at the Psychiatric Department of the University Hospital Center of Brazzaville  

作　　者：Landry Martial Miguel Paul Gandou Justecidi Kiang Choupette Ravelle Dobhat-Doukakini Didier Gesril Njilo Tchatchouang Childerick Lekana Destin Mbemba Bahamboula Archange Emmanuel Mboungou Malonga Donatien Moukassa Alain Maxime Mouanga Ange Antoine Abena Landry Martial Miguel;Paul Gandou;Justecidi Kiang;Choupette Ravelle Dobhat-Doukakini;Didier Gesril Njilo Tchatchouang;Childerick Lekana;Destin Mbemba Bahamboula;Archange Emmanuel Mboungou Malonga;Donatien Moukassa;Alain Maxime Mouanga;Ange Antoine Abena(Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo;Psychiatric Department, University Hospital Center, Brazzaville, Republic of Congo;Department of Biological Sciences, Dnis Sassou-NGuesso University, Kintl, Republic of Congo)

机构地区：[1]Biochemical and Pharmacology Laboratory, Faculty of Health Sciences, Marien Ngouabi University, Brazzaville, Republic of Congo [2]Psychiatric Department, University Hospital Center, Brazzaville, Republic of Congo [3]Department of Biological Sciences, Dnis Sassou-NGuesso University, Kintl, Republic of Congo

出　　处：《Journal of Biosciences and Medicines》2024年第6期33-42,共10页生物科学与医学（英文）

摘　　要：Several studies report the problem of cardiovascular tolerance of treatments with neuroleptics, given the important number of morbidities in patients with mental illnesses. This preliminary work aimed to describe the epidemiological and biological profile of patients taking neuroleptics and followed in the psychiatry department of Brazzaville University Hospital, from the angle of cardiovascular risk. Fifty (50) patients (17 men and 33 women), with a mean age of 33.9 10.7 years, were included. Epidemiological data (sex, age, tobacco or alcohol consumption) were collected on pre-established survey forms. Biochemical (total cholesterol, HDL-c, triglycerides and atherogenicity index) and inflammatory parameters (ultra-sensitive CRP, troponin I and NT-ProBNP) were investigated using enzymatic and indirect immunofluorescence technical, respectively. The results obtained showed that 54% of patients were obese, 94% were non-smokers, and 12% had high blood pressure. 10% of patients had high total cholesterol levels and 90% had HDL cholesterol levels below 60 mg/dl. Triglycerides and atherogenicity index were significantly elevated in relation to Body Mass Index (BMI). Ultrasensitive CRP was elevated in 38% of patients. In conclusion, this study revealed an association between lipid parameters (triglycerides and atherogenicity index) in relation to BMI in patients taking neuroleptics followed in the Psychiatry Department of University Hospital Center of Brazzaville.Several studies report the problem of cardiovascular tolerance of treatments with neuroleptics, given the important number of morbidities in patients with mental illnesses. This preliminary work aimed to describe the epidemiological and biological profile of patients taking neuroleptics and followed in the psychiatry department of Brazzaville University Hospital, from the angle of cardiovascular risk. Fifty (50) patients (17 men and 33 women), with a mean age of 33.9 10.7 years, were included. Epidemiological data (sex, age, tobacco or alcohol consumption) were collected on pre-established survey forms. Biochemical (total cholesterol, HDL-c, triglycerides and atherogenicity index) and inflammatory parameters (ultra-sensitive CRP, troponin I and NT-ProBNP) were investigated using enzymatic and indirect immunofluorescence technical, respectively. The results obtained showed that 54% of patients were obese, 94% were non-smokers, and 12% had high blood pressure. 10% of patients had high total cholesterol levels and 90% had HDL cholesterol levels below 60 mg/dl. Triglycerides and atherogenicity index were significantly elevated in relation to Body Mass Index (BMI). Ultrasensitive CRP was elevated in 38% of patients. In conclusion, this study revealed an association between lipid parameters (triglycerides and atherogenicity index) in relation to BMI in patients taking neuroleptics followed in the Psychiatry Department of University Hospital Center of Brazzaville.

关 键 词：NEUROLEPTIC Cardiovascular Risk PSYCHIATRY BRAZZAVILLE 

分 类 号：R74[医药卫生—神经病学与精神病学]