Endogenous Endophthalmitis as a Triggering Factor for Fatal Bacterial Meningitis Caused by Streptococcus pneumoniae: A Case Report  

作　　者：David Fernando Ortiz-Pérez Mario Enrique Montoya-Jaramillo Juan Pablo de la Ossa Díaz Natalia Vanessa Benavides-Garzón Luis Augusto Martínez-Aguilera Luis Miguel Orozco-Pabón Santiago José González-Manzur Víctor Santiago Márquez-Camacho Miguel Gregorio Tordecilla-Castro Gustavo Alberto Gutiérrez Barros John Sebastián Osorio-Muñoz David Fernando Ortiz-Pérez;Mario Enrique Montoya-Jaramillo;Juan Pablo de la Ossa Díaz;Natalia Vanessa Benavides-Garzón;Luis Augusto Martínez-Aguilera;Luis Miguel Orozco-Pabón;Santiago José González-Manzur;Víctor Santiago Márquez-Camacho;Miguel Gregorio Tordecilla-Castro;Gustavo Alberto Gutiérrez Barros;John Sebastián Osorio-Muñoz(Department of Internal Medicine, Cartagena del Mar Medical Center, Cartagena, Colombia;MEDISTAR Internal Medicine Research Group, Cartagena, Colombia;Internal Medicine Program, Universidad del Sin, Cartagena, Colombia)

机构地区：[1]Department of Internal Medicine, Cartagena del Mar Medical Center, Cartagena, Colombia [2]MEDISTAR Internal Medicine Research Group, Cartagena, Colombia [3]Internal Medicine Program, Universidad del Sin, Cartagena, Colombia

出　　处：《Journal of Biosciences and Medicines》2024年第10期97-104,共8页生物科学与医学（英文）

摘　　要：Endogenous endophthalmitis is a rare condition with a poor long-term visual prognosis and significant mortality, often associated with the hematogenous spread of intravitreal infections and subsequent disruption of the blood-ocular barrier. Its anatomical proximity to the central nervous system (CNS) poses a high risk of infection dissemination, although cases documented in the literature are rare, and endogenous endophthalmitis is typically described as secondary to neuroinfections. We report the case of an 82-year-old female patient with a history of hypertension who presented with fever, decreased visual acuity, severe headache, chemosis, and conjunctival injection. Endogenous endophthalmitis was diagnosed, and antimicrobial treatment was initiated alongside surgical intervention by the ophthalmology service. However, the patient’s condition worsened neurologically, and Streptococcus pneumoniae was identified in cerebrospinal fluid cultures. Despite intensive medical treatment, the patient’s clinical course was poor, leading to death.Endogenous endophthalmitis is a rare condition with a poor long-term visual prognosis and significant mortality, often associated with the hematogenous spread of intravitreal infections and subsequent disruption of the blood-ocular barrier. Its anatomical proximity to the central nervous system (CNS) poses a high risk of infection dissemination, although cases documented in the literature are rare, and endogenous endophthalmitis is typically described as secondary to neuroinfections. We report the case of an 82-year-old female patient with a history of hypertension who presented with fever, decreased visual acuity, severe headache, chemosis, and conjunctival injection. Endogenous endophthalmitis was diagnosed, and antimicrobial treatment was initiated alongside surgical intervention by the ophthalmology service. However, the patient’s condition worsened neurologically, and Streptococcus pneumoniae was identified in cerebrospinal fluid cultures. Despite intensive medical treatment, the patient’s clinical course was poor, leading to death.

关 键 词：Central Nervous System Infections MENINGITIS Infectious Disease Medicine Endogenous Endophthalmitis 

分 类 号：R73[医药卫生—肿瘤]