A Rare Case of Mycobacterium Avium Combined with Penicillium marneffei (PM) Infection Involving Multiple Bone Joints throughout the Whole Body: A Case Report  

作　　者：Fouejio Yemele Eunice Xiuxiu Zheng Chenhong Yan Yitong Zhang Lujun Dai Er Jin Fouejio Yemele Eunice;Xiuxiu Zheng;Chenhong Yan;Yitong Zhang;Lujun Dai;Er Jin(Department of Pulmonary and Critical Care Medicine, Affiliated Hangzhou Peoples University, Zhejiang Chinese Medical University, Hangzhou, China;Department of Nephrology, Yiwu Central Hospital, Yiwu, China;Department of Pulmonary and Critical Care Medicine, Affiliated Hangzhou Peoples University, Zhejiang University School of Medicine, Hangzhou, China)

机构地区：[1]Department of Pulmonary and Critical Care Medicine, Affiliated Hangzhou Peoples University, Zhejiang Chinese Medical University, Hangzhou, China [2]Department of Nephrology, Yiwu Central Hospital, Yiwu, China [3]Department of Pulmonary and Critical Care Medicine, Affiliated Hangzhou Peoples University, Zhejiang University School of Medicine, Hangzhou, China

出　　处：《Journal of Biosciences and Medicines》2024年第11期15-29,共15页生物科学与医学（英文）

摘　　要：Background: Mycobacterium avium complex (MAC) infection case which involves bones and joints are rare scenarios. Here, we report a rare case of Penicillium marneffei (PM), lung infection and systemic multi joint damage reported with positive anti-interferon-gamma at the same time. Case Presentation: A 55-year-old woman with fever for 10 days due to repeated multiple joint pain for more than one month was admitted to our hospital on September 19th 2020. During hospitalization, the patient was confirmed with mycobacterium avium combined with Penicillium marneffei (PM) infection involving multiple bone joints. Antifungal therapy and immunity regulatory agent were given during hospitalization. Following pharmocol-therapy, symptoms gradually improved, and the patient was discharged. Conclusions: The patient was considered disseminated and refractory non-tubercular mycobacterium (NTM) combined with Penicillium marneffei infection. In addition, we found that anti IFN-γ autoantibodies are closely related. Although the current incidence of this patient is related to anti IFN-γ, there is a strong correlation between autoantibody-mediated immunodeficiency in adults.Background: Mycobacterium avium complex (MAC) infection case which involves bones and joints are rare scenarios. Here, we report a rare case of Penicillium marneffei (PM), lung infection and systemic multi joint damage reported with positive anti-interferon-gamma at the same time. Case Presentation: A 55-year-old woman with fever for 10 days due to repeated multiple joint pain for more than one month was admitted to our hospital on September 19th 2020. During hospitalization, the patient was confirmed with mycobacterium avium combined with Penicillium marneffei (PM) infection involving multiple bone joints. Antifungal therapy and immunity regulatory agent were given during hospitalization. Following pharmocol-therapy, symptoms gradually improved, and the patient was discharged. Conclusions: The patient was considered disseminated and refractory non-tubercular mycobacterium (NTM) combined with Penicillium marneffei infection. In addition, we found that anti IFN-γ autoantibodies are closely related. Although the current incidence of this patient is related to anti IFN-γ, there is a strong correlation between autoantibody-mediated immunodeficiency in adults.

关 键 词：Systemic Multiple Osteoarticular Mycobacterium Avium Complex Penicillium marneffei Anti IFN-γ Auto-Antibody 

分 类 号：R73[医药卫生—肿瘤]