Sickle Cell Trait in Kisangani: Prevalence and Opinion of Carriers towards the Choice of a Potential Carrier Spouse  

作　　者：Junior Lisi-Ankiene Burubu Jean-Jeannot Sihalikyolo Juakali Noël Labama Otuli Jean-Didier Nguma Bosenge Teddy Habiragi Matega Yvette Ufoy Mungu Neema Jean-Marie Lukangi Demupondo Paul Kombi Kambale Gédéon Bosunga Katenga Junior Lisi-Ankiene Burubu;Jean-Jeannot Sihalikyolo Juakali;Noël Labama Otuli;Jean-Didier Nguma Bosenge;Teddy Habiragi Matega;Yvette Ufoy Mungu Neema;Jean-Marie Lukangi Demupondo;Paul Kombi Kambale;Gédéon Bosunga Katenga(Department of Gynecology and Obstetrics, Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo;Department of Gynecology and Obstetrics, Faculty of Medicine, University of Kikwit, Kikwit, Democratic Republic of the Congo;Hospital of the Congolese National Police, Kisangani, Democratic Republic of the Congo;Department of Gynecology and Obstetrics, Faculty of Medicine, University of Kindu, Kindu, Democratic Republic of the Congo;Department of Internal Medicine, Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo)

机构地区：[1]Department of Gynecology and Obstetrics, Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo [2]Department of Gynecology and Obstetrics, Faculty of Medicine, University of Kikwit, Kikwit, Democratic Republic of the Congo [3]Hospital of the Congolese National Police, Kisangani, Democratic Republic of the Congo [4]Department of Gynecology and Obstetrics, Faculty of Medicine, University of Kindu, Kindu, Democratic Republic of the Congo [5]Department of Internal Medicine, Faculty of Medicine and Pharmacy, University of Kisangani, Kisangani, Democratic Republic of the Congo

出　　处：《Journal of Biosciences and Medicines》2025年第2期202-217,共16页生物科学与医学(英文)

摘　　要：Introduction: Sickle cell disease is one of the most common autosomal recessive inherited diseases. Its prevalence is increasing due to the perpetuity of carriers of the trait who are able to marry. Women aged 18 to 35 years constitute the most reproductive age group. This study was conducted with the aim of determining the prevalence of sickle cell trait among women aged 18 to 35 years and the attitude of women carriers towards the choice of a carrier spouse. Materials and methods: This was a cross-sectional descriptive study with analytical aims conducted from March to September 2024 in Kisangani. A total of 215 women aged 18 to 35 years presented for screening for sickle cell trait. This study described the following parameters: Sociodemographic data (age, level of education, socioeconomic level, marital status), obstetric and medical history (obstetric formula, sickle cell disease, high blood pressure, diabetes mellitus, asthma), knowledge of sickle cell disease (etiological classification, transmission, prevention, high-risk marriages, clinical manifestations, progression of the disease), attitude of the woman in relation to the choice of an AS spouse, as well as the reasons justifying each attitude. Results: The prevalence of sickle cell trait was 23.7% (51/215). A total of 64.3% of respondents had accepted the choice of spouse before confirmation of carrier status and 73.8% had refused after confirmation of carrier status. Choice was significantly related to age (p-value = 0.027), occupation (p-value = 0.015), parity (p-value = 0.039) and gesture (p-value = 0.034) before test. The ignorance of the union at risk was associated with the risk (p = 0.005;OR: 9.10;CI 95%: 2.03 - 4.81) of accepting the choice of a spouse carrying the trait. Conclusion: The prevalence of sickle cell trait among women aged 18 to 35 years in Kisangani remains within the limits of that of the general population. The choice of a spouse carrying sickle cell trait is associated with the woman’s age, her profession, parity, gestation Introduction: Sickle cell disease is one of the most common autosomal recessive inherited diseases. Its prevalence is increasing due to the perpetuity of carriers of the trait who are able to marry. Women aged 18 to 35 years constitute the most reproductive age group. This study was conducted with the aim of determining the prevalence of sickle cell trait among women aged 18 to 35 years and the attitude of women carriers towards the choice of a carrier spouse. Materials and methods: This was a cross-sectional descriptive study with analytical aims conducted from March to September 2024 in Kisangani. A total of 215 women aged 18 to 35 years presented for screening for sickle cell trait. This study described the following parameters: Sociodemographic data (age, level of education, socioeconomic level, marital status), obstetric and medical history (obstetric formula, sickle cell disease, high blood pressure, diabetes mellitus, asthma), knowledge of sickle cell disease (etiological classification, transmission, prevention, high-risk marriages, clinical manifestations, progression of the disease), attitude of the woman in relation to the choice of an AS spouse, as well as the reasons justifying each attitude. Results: The prevalence of sickle cell trait was 23.7% (51/215). A total of 64.3% of respondents had accepted the choice of spouse before confirmation of carrier status and 73.8% had refused after confirmation of carrier status. Choice was significantly related to age (p-value = 0.027), occupation (p-value = 0.015), parity (p-value = 0.039) and gesture (p-value = 0.034) before test. The ignorance of the union at risk was associated with the risk (p = 0.005;OR: 9.10;CI 95%: 2.03 - 4.81) of accepting the choice of a spouse carrying the trait. Conclusion: The prevalence of sickle cell trait among women aged 18 to 35 years in Kisangani remains within the limits of that of the general population. The choice of a spouse carrying sickle cell trait is associated with the woman’s age, her profession, parity, gestation

关 键 词：Sickle Cell Trait PREVALENCE Attitude of Carriers Choice of Spouse 

分 类 号：R73[医药卫生—肿瘤]