A Comparative Study of the Recurrence Rate in Hypofractionated versus Conventional Postmastectomy Radiation in Breast Cancer  

作　　者：Aravindh Sivanandan Anand Abul Hussain Mirsa Amina Basheer Aravindh Sivanandan Anand;Abul Hussain Mirsa;Amina Basheer(Department of Radiation Oncology, Government Medical College, Trivandrum, India;Department of Pharmacology, Government Medical College, Trivandrum, India)

机构地区：[1]Department of Radiation Oncology, Government Medical College, Trivandrum, India [2]Department of Pharmacology, Government Medical College, Trivandrum, India

出　　处：《Journal of Cancer Therapy》2021年第12期736-750,共15页癌症治疗（英文）

摘　　要：<strong>Background:</strong><span style="font-family:Verdana;"> Treatment options available for breast cancer are Surgery [Breast conservation surgery (BCS) or Modified radical mastectomy (MRM)];Radiation treatment [Conventional radiation treatment or CRT and Hypofractionated radiation treatment or HRT] and Chemotherapy. In the postmastectomy or post lumpectomy setting, radiotherapy (RT) improves loco-regional control. CRT for breast include</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 50</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy in 25 fractions (2</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy per fraction) and HRT include</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 42.5</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy in 16 fractions (2.7</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy per fraction) or extreme hypofractionation like 26</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy in 5 fraction</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;">. Alpha/beta value for breast is less, so HRT is ideal for breast. So, there will be good loco-regional control, without increased normal tissue damage. This study aims to identify recurrence rate and toxicity in breast cancer patients treated using conventional and hypofractionated postmastectomy radiotherapy among Indian population. </span><b><span style="font-family:Verdana;">Primary objective: </span></b><span style="font-family:Verdana;">To assess recurrence rate of disease in breast cancer patients treated using hypofractionated postmastectomy radiation and to compare it with breast cancer patients treated using conventional postmastectomy radiation. </span><b><span style="font-family:Verdana;">Secondary objective:</span></b><span style="font-family:Verdana;"> <strong>Background:</strong><span style="font-family:Verdana;"> Treatment options available for breast cancer are Surgery [Breast conservation surgery (BCS) or Modified radical mastectomy (MRM)];Radiation treatment [Conventional radiation treatment or CRT and Hypofractionated radiation treatment or HRT] and Chemotherapy. In the postmastectomy or post lumpectomy setting, radiotherapy (RT) improves loco-regional control. CRT for breast include</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 50</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy in 25 fractions (2</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy per fraction) and HRT include</span><span style="font-family:Verdana;">s</span><span style="font-family:Verdana;"> 42.5</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy in 16 fractions (2.7</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy per fraction) or extreme hypofractionation like 26</span><span style="font-family:""> </span><span style="font-family:Verdana;">Gy in 5 fraction</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;">. Alpha/beta value for breast is less, so HRT is ideal for breast. So, there will be good loco-regional control, without increased normal tissue damage. This study aims to identify recurrence rate and toxicity in breast cancer patients treated using conventional and hypofractionated postmastectomy radiotherapy among Indian population. </span><b><span style="font-family:Verdana;">Primary objective: </span></b><span style="font-family:Verdana;">To assess recurrence rate of disease in breast cancer patients treated using hypofractionated postmastectomy radiation and to compare it with breast cancer patients treated using conventional postmastectomy radiation. </span><b><span style="font-family:Verdana;">Secondary objective:</span></b><span style="font-family:Verdana;">

关 键 词：Breast Cancer Post Mastectomy Radiation CONVENTIONAL HYPOFRACTIONATION Recurrence Rate Acute Toxicity 

分 类 号：R73[医药卫生—肿瘤]