Hair Growth Promoting Effect of Trichoxidil<up>TM</up>: A New Natural Compound for Hair Loss  

作　　者：Glaucia Labinas Fernando Amaral Valeria Maria de Souza Antunes Maira Jardim Leonardo Mendes Bella Carlos Rocha Oliveira Glaucia Labinas;Fernando Amaral;Valeria Maria de Souza Antunes;Maira Jardim;Leonardo Mendes Bella;Carlos Rocha Oliveira(Universidade Anhembi Morumbi, São Paulo, Brazil)

机构地区：[1]Universidade Anhembi Morumbi, Sã o Paulo, Brazil

出　　处：《Journal of Cosmetics, Dermatological Sciences and Applications》2020年第4期176-190,共15页化妆品、皮肤病及应用期刊（英文）

摘　　要：<strong>Background:</strong> Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of Trichoxidil^TM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. <strong>Methods:</strong> The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of Trichoxidil^TM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);Trichosol^TM vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);Trichosol^TM vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);Trichosol^TM group with 2.5% Trichoxidil^TM (n = 5) and Hydroalcoholic vehicle group with 2.5% Trichoxidil^TM (n = 4) to dermoscopic and histologic. <strong>Results:</strong> Fibroblasts exhibited higher proliferation when treated with higher concentrations of Trichoxidil^TM. Trichoxidil^TM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that Trichoxidil^TM associated with Trichosol^TM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. <strong>Conclusion:</strong> Trichoxidil^TM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.<strong>Background:</strong> Androgenetic alopecia (AGA) is a most common condition of hair loss. Thus, the present study aimed to investigate the effect of Trichoxidil^TM, a phytocomplex obtained from a blend of essential oils, in the treatment of hair loss caused by AGA. <strong>Methods:</strong> The CCD1072Sk cells were cultured for the 24-hour cell viability assessment and cytotoxicity of Trichoxidil^TM. The expression of mRNA levels from KGF, IGF-1, and VEGF in fibroblasts was evaluated by RT-qPCR. Thirty-three volunteers, diagnosed with AGA, men and women, aged between 25 and 50 years, were divided into Control group, without treatment (n = 5);Trichosol^TM vehicle group, without active (n = 5);Hydroalcoholic vehicle group, without active (n = 4);Trichosol^TM vehicle group, with 2.5% minoxidil (n = 5);Hydroalcoholic vehicle group, with 2.5% minoxidil (n = 5);Trichosol^TM group with 2.5% Trichoxidil^TM (n = 5) and Hydroalcoholic vehicle group with 2.5% Trichoxidil^TM (n = 4) to dermoscopic and histologic. <strong>Results:</strong> Fibroblasts exhibited higher proliferation when treated with higher concentrations of Trichoxidil^TM. Trichoxidil^TM significantly increased the expression of KGF, IGF-1, and VEGF mRNA in fibroblasts cells. Analysis of the capillary density showed that Trichoxidil^TM associated with Trichosol^TM vehicle, was the most effective association. In addition, it was observed an increased more effectively the percentage of anagen phase and reduction of the telogen when compared to other formulations. <strong>Conclusion:</strong> Trichoxidil^TM promoted proliferative effects and positively modulated the expression of growth factors IGF-1, VEGF, and KGF, being a promising candidate for the treatment of hair loss caused by AGA.

关 键 词：TrichoxidilTM Hair Growth Anagen TELOGEN KGF IGF-1 

分 类 号：R73[医药卫生—肿瘤]