The effect of age, gender, level of adiposity and diabetes duration on glycated hemoglobin reduction after anti-diabetic therapy in type-2 diabetic patients  

作　　者：Chinwe O. Ewenighi Uchechukwu Dimkpa Babatunde I. Adejumo Joel C. Onyeanusi Isaac N. Nnatuanya Uzor Simon Linus U. M. Onoh Uchechukwu Ezeugwu 

机构地区：[1]Department of Chemical Pathology/Toxicology, Faculty of Medical Lab Sciences, Elele Campus, Madonna University, Okija, Nigeria [2]Department of Community Medicine, Enugu State University of Science and Technology, Enugu, Nigeria [3]Department of Physiotherapy, University of Nigeria Teaching Hospital, Enugu, Nigeria [4]Medical Laboratory Science Department, Ebonyi State University, Abakaliki, Nigeria [5]Medical Laboratory Science Department, University of Benin, Benin City, Nigeria [6]Physiology Department, Nnewi Campus, Nnamdi Azikiwe University, Enugu, Nigeria

出　　处：《Journal of Diabetes Mellitus》2012年第2期245-250,共6页糖尿病（英文）

摘　　要：Background: It is established that glycemic control measures involving diet and oral medication reduce glycated hemoglobin concentration (HbA1c) in type-2 diabetic patients. Aim: We aimed to determine whether HbA1c reduction after diabetic treatment is affected by age, gender, level of adiposity and diabetes duration in type-2 diabetic patients. Methods: One hundred and four type-2 diabetic patients participated in a 20-week diabetic control therapy involving oral medication (metformin) and lifestyle intervention (diet). We compared the HbA1c reduction after treatment between the elderly and non-elderly;males and females;overweight/obese and non-overweight/obese;and long-standing and newly diagnosed patients. Results: After the treatment, participants had mean HbA1c reduction of 1.1 ± 1.31% and weight loss of 2.46 ± 1.79 kg. Forty-six (44.2%) of the patients had acceptable HbA1c level of p p p < 0.001), respectively. HbA1c reduction did not indicate significant sex differences. Conclusion: The present findings suggest that treatment criteria for type-2 diabetes should account for the age, level of adiposity and diabetes duration of the patient in order to make optimal therapeutic decisions for the treatment of diabetes mellitus in adults.Background: It is established that glycemic control measures involving diet and oral medication reduce glycated hemoglobin concentration (HbA1c) in type-2 diabetic patients. Aim: We aimed to determine whether HbA1c reduction after diabetic treatment is affected by age, gender, level of adiposity and diabetes duration in type-2 diabetic patients. Methods: One hundred and four type-2 diabetic patients participated in a 20-week diabetic control therapy involving oral medication (metformin) and lifestyle intervention (diet). We compared the HbA1c reduction after treatment between the elderly and non-elderly;males and females;overweight/obese and non-overweight/obese;and long-standing and newly diagnosed patients. Results: After the treatment, participants had mean HbA1c reduction of 1.1 ± 1.31% and weight loss of 2.46 ± 1.79 kg. Forty-six (44.2%) of the patients had acceptable HbA1c level of p p p < 0.001), respectively. HbA1c reduction did not indicate significant sex differences. Conclusion: The present findings suggest that treatment criteria for type-2 diabetes should account for the age, level of adiposity and diabetes duration of the patient in order to make optimal therapeutic decisions for the treatment of diabetes mellitus in adults.

关 键 词：Glycated HEMOGLOBIN Age GENDER ADIPOSITY METFORMIN DIET 

分 类 号：R5[医药卫生—内科学]