Visfatin levels are low in subjects with type 2 diabetes compared to age-matched controls  被引量:1

Visfatin levels are low in subjects with type 2 diabetes compared to age-matched controls

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作  者:Subhashini Yaturu Jared Davis LaTonya Franklin Runhua Shi Prasanna Venkatesh Sushil K. Jain 

机构地区:[1]Department of Medicine, Stratton VA Medical Center/AMC, Albany, USA [2]Department of Research, Overton Brooks VA Medical Center, Shreveport, USA [3]Louisiana State University Health Sciences Center, Shreveport, USA [4]Overton Brooks VA Medical Center/LSUHSC, Shreveport, USA

出  处:《Journal of Diabetes Mellitus》2012年第4期373-377,共5页糖尿病(英文)

摘  要:Background: Visceral adiposity correlates strongly with insulin resistance and components of metabolic syndrome. Visfatin is preferentially produced by human visceral adipose tissue. Objective: The objective of this study was to evaluate the relationship between circulating levels of visfatin and other adipocytokines in patients with type 2 diabetes (DM) compared to the age-matched control subjects without DM. Methods: Anthropometric parameters, lipid profiles, high-sensitivity CRP (hs-CRP), insulin resistance [HOMA-IR], and levels of visfatin, TNF-α, and resistin were evaluated in 55 subjects with diabetes and 56 age matched control subjects without diabetes. Results: The visfatin levels were significantly lower in subjects with diabetes (p < 0.0001). Visfatin levels correlated strongly with resistin and CRP. We noted negative correlation of visfatin levels with BMI, triglycerides and glucose. Conclusion: These data suggest that visfatin may be a marker of subclinical inflammatory state.Background: Visceral adiposity correlates strongly with insulin resistance and components of metabolic syndrome. Visfatin is preferentially produced by human visceral adipose tissue. Objective: The objective of this study was to evaluate the relationship between circulating levels of visfatin and other adipocytokines in patients with type 2 diabetes (DM) compared to the age-matched control subjects without DM. Methods: Anthropometric parameters, lipid profiles, high-sensitivity CRP (hs-CRP), insulin resistance [HOMA-IR], and levels of visfatin, TNF-α, and resistin were evaluated in 55 subjects with diabetes and 56 age matched control subjects without diabetes. Results: The visfatin levels were significantly lower in subjects with diabetes (p < 0.0001). Visfatin levels correlated strongly with resistin and CRP. We noted negative correlation of visfatin levels with BMI, triglycerides and glucose. Conclusion: These data suggest that visfatin may be a marker of subclinical inflammatory state.

关 键 词:VISFATIN ADIPONECTIN RESISTIN Diabetes Insulin Resistance TNF-α BMI Metabolic Syndrome VISCERAL ADIPOSITY 

分 类 号:R5[医药卫生—内科学]

 

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