Relationship between Serum Leptin and Adiponectin Levels in Obese Nigerians with Type 2 Diabetes Subjects  

作　　者：Rosemary Temidayo Ikem Ugochukwu Rosemary Mosanya Gbadebo Oladimeji David Ajani Okechukwu Obumneme Ezekpo David Olubukunmi Soyoye Rosemary Temidayo Ikem;Ugochukwu Rosemary Mosanya;Gbadebo Oladimeji David Ajani;Okechukwu Obumneme Ezekpo;David Olubukunmi Soyoye(Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria;Department of Orthopaedic Surgery & Traumatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria;Department of Medicine, Afe Babalola University Ado Ekiti & Federal Medical Teaching Hospital, Ido Ekiti, Nigeria;Department of Medicine, Afe Babalola University & Multi-System Hospital, Ado Ekiti, Nigeria)

机构地区：[1]Department of Medicine, Obafemi Awolowo University, Ile Ife, Nigeria [2]Department of Orthopaedic Surgery & Traumatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile Ife, Nigeria [3]Department of Medicine, Afe Babalola University Ado Ekiti & Federal Medical Teaching Hospital, Ido Ekiti, Nigeria [4]Department of Medicine, Afe Babalola University & Multi-System Hospital, Ado Ekiti, Nigeria

出　　处：《Journal of Diabetes Mellitus》2023年第3期248-256,共9页糖尿病（英文）

摘　　要：Background: Obesity is rising globally, independent of ethnicity, race and age, and is associated with increased risk of cardiovascular mortality and morbidity especially in persons living with diabetes. The effect of adipokines such as leptin, resistin and adiponectin which are secreted by adipose tissue factors has been linked to the increased risk of the cardiovascular mortality and morbidity. Aim: This study aims to assess the levels of serum leptin and serum adiponectin in obese type 2 diabetes subjects, and their relationship with cardio-metabolic component (using lipid profile). Method: This is a cross-sectional comparative hospital-based study in which one hundred and fifty participants grouped into 60 obese, 60 non-obese none diabetic and 30 non-obese non-diabetic adults with similar age from the Endocrinology outpatient’s clinic, General outpatient department (GOPD) and staff clinic of Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC). Anthropometric parameters and other relevant clinical details of all subjects were obtained. Fasting venous blood samples were taken from all subjects for the determination of fasting plasma glucose (FPG), fasting lipid profile, glycosylated haemoglobin levels (HbA_1C), fasting serum insulin, leptin, and adiponectin. Data was analysed using the Statistical Package of Social Sciences (SPSS) version 23.0. Results: Twenty-eight (46.7%)) subjects were males while 32 subjects (53.3%) were females (in obese groups). There was no statistical difference between these two groups for both sexes (p = 1.000). The age range for all subjects was 34 to 64 years with their mean age being 52 ± 7.3 years, and for type 2 subjects and the obese non-diabetic 50.7 ± 7.3 years respectively. The mean body mass index of the non-obese and non-diabetic was 23.7 ± 4 Kg/m² while the anthropometric measurements of the obese two groups were similar. The lipid profile, serum leptin and adiponectin in both the obese groups showed no difference. The relationship betwBackground: Obesity is rising globally, independent of ethnicity, race and age, and is associated with increased risk of cardiovascular mortality and morbidity especially in persons living with diabetes. The effect of adipokines such as leptin, resistin and adiponectin which are secreted by adipose tissue factors has been linked to the increased risk of the cardiovascular mortality and morbidity. Aim: This study aims to assess the levels of serum leptin and serum adiponectin in obese type 2 diabetes subjects, and their relationship with cardio-metabolic component (using lipid profile). Method: This is a cross-sectional comparative hospital-based study in which one hundred and fifty participants grouped into 60 obese, 60 non-obese none diabetic and 30 non-obese non-diabetic adults with similar age from the Endocrinology outpatient’s clinic, General outpatient department (GOPD) and staff clinic of Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC). Anthropometric parameters and other relevant clinical details of all subjects were obtained. Fasting venous blood samples were taken from all subjects for the determination of fasting plasma glucose (FPG), fasting lipid profile, glycosylated haemoglobin levels (HbA_1C), fasting serum insulin, leptin, and adiponectin. Data was analysed using the Statistical Package of Social Sciences (SPSS) version 23.0. Results: Twenty-eight (46.7%)) subjects were males while 32 subjects (53.3%) were females (in obese groups). There was no statistical difference between these two groups for both sexes (p = 1.000). The age range for all subjects was 34 to 64 years with their mean age being 52 ± 7.3 years, and for type 2 subjects and the obese non-diabetic 50.7 ± 7.3 years respectively. The mean body mass index of the non-obese and non-diabetic was 23.7 ± 4 Kg/m² while the anthropometric measurements of the obese two groups were similar. The lipid profile, serum leptin and adiponectin in both the obese groups showed no difference. The relationship betw

关 键 词：Obesity Type 2 DM LEPTIN ADIPOKINES 

分 类 号：R58[医药卫生—内分泌]