Dyslipidemia in Adults with Type 2 Diabetes in a Rural Community in Ganadougou, Mali: A Cross-Sectional Study  

作　　者：Abdoulaye Diawara Djibril Mamadou Coulibaly Drissa Kone Mama A. Traore Drissa Konaté Dicko S. Bazi Oumar Kassogue Djeneba Sylla Fatoumata Gniné Fofana Oudou Diabaté Mariam Traore Ibrahim Antoine Nieantao Kaly Keїta Mamadou Diarra Olivia Smith Jian Li Cheickna Cisse Talib Yusuf Abbas Crystal Zheng Segun Fatumo Kassim Traore Mamadou Wele Mahamadou Diakité Seydou O. Doumbia Jeffrey G. Shaffer Abdoulaye Diawara;Djibril Mamadou Coulibaly;Drissa Kone;Mama A. Traore;Drissa Konaté;Dicko S. Bazi;Oumar Kassogue;Djeneba Sylla;Fatoumata Gniné Fofana;Oudou Diabaté;Mariam Traore;Ibrahim Antoine Nieantao;Kaly Keїta;Mamadou Diarra;Olivia Smith;Jian Li;Cheickna Cisse;Talib Yusuf Abbas;Crystal Zheng;Segun Fatumo;Kassim Traore;Mamadou Wele;Mahamadou Diakité;Seydou O. Doumbia;Jeffrey G. Shaffer(University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali;National Federation of Community Health Associations, Bamako, Mali;Department of Tropical Medicine, Medical Microbiology, & Pharmacology, John A. Burns School of Medicine, University of Hawaii Manoa, Honolulu, USA;Department Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA;Department of Biotechnology and Computer Science, Burhani College, Mazgaon, Mumbai, India;School of Medicine, Tulane University, New Orleans, USA;Medical Research Council, Uganda Virus Research Institute, Entebbe, Uganda;London School of Hygiene and Tropical Medicine, London, UK;Departement of Biochemistry and Genetics Duquesne, University College of Medicine, Pittsburgh, USA)

机构地区：[1]University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali [2]National Federation of Community Health Associations, Bamako, Mali [3]Department of Tropical Medicine, Medical Microbiology, & Pharmacology, John A. Burns School of Medicine, University of Hawaii Manoa, Honolulu, USA [4]Department Biostatistics and Data Science, School of Public Health and Tropical Medicine, Tulane University, New Orleans, USA [5]Department of Biotechnology and Computer Science, Burhani College, Mazgaon, Mumbai, India [6]School of Medicine, Tulane University, New Orleans, USA [7]Medical Research Council, Uganda Virus Research Institute, Entebbe, Uganda [8]London School of Hygiene and Tropical Medicine, London, UK [9]Departement of Biochemistry and Genetics Duquesne, University College of Medicine, Pittsburgh, USA

出　　处：《Journal of Diabetes Mellitus》2024年第2期133-152,共20页糖尿病（英文）

摘　　要：Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (P = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (P = .013 and.036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (P = .029 and .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.Dyslipidemia is a disorder where abnormally lipid concentrations circulate in the bloodstream. The disorder is common in type 2 diabetics (T2D) and is linked with T2D comorbidities, particularly cardiovascular disease. Dyslipidemia in T2D is typically characterized by elevated plasma triglyceride and low high-density lipoprotein cholesterol (HDL-C) levels. There is a significant gap in the literature regarding dyslipidemia in rural parts of Africa, where lipid profiles may not be captured through routine surveillance. This study aimed to characterize the prevalence and demo-graphic profile of dyslipidemia in T2D in the rural community of Ganadougou, Mali. We performed a cross-sectional study of 104 subjects with T2D in Ganadougou between November 2021 and March 2022. Demographic and lipid profiles were collected through cross-sectional surveys and serological analyses. The overall prevalence of dyslipidemia in T2D patients was 87.5% (91/104), which did not differ by sex (P = .368). High low-density lipoprotein cholesterol (LDL-C) was the most common lipid abnormality (78.9%, [82/104]). Dyslipidemia was associated with age and hypertension status (P = .013 and.036, respectively). High total and high LDL-C parameters were significantly associated with hypertension (P = .029 and .006, respectively). In low-resource settings such as rural Mali, there is a critical need to improve infrastructure for routine dyslipidemia screening to guide its prevention and intervention approaches. The high rates of dyslipidemia observed in Gandadougou, consistent with concomitant increases in cardiovascular diseases in Africa suggest that lipid profile assessments should be incorporated into routine medical care for T2D patients in African rural settings.

关 键 词：CHOLESTEROL Cross-Sectional Study DYSLIPIDEMIA LIPIDS MALI Type 2 Diabetes 

分 类 号：R58[医药卫生—内分泌]