Procalcitonin—A Useful Biomarker for Pneumonia Associated with Rhodococcus equi?  

作　　者：Ann Kristin Barton Martin Rieger Dana Teschner Heidrun Gehlen Ann Kristin Barton;Martin Rieger;Dana Teschner;Heidrun Gehlen(Equine Clinic, Veterinary Faculty, Freie Universitaet Berlin, Berlin, Germany;Helmholtz Center, München, Germany)

机构地区：[1]Equine Clinic, Veterinary Faculty, Freie Universitaet Berlin, Berlin, Germany [2]Helmholtz Center, München, Germany

出　　处：《Modern Research in Inflammation》2016年第2期13-19,共7页炎症（英文）

摘　　要：Background: Procalcitonin, a precursor protein of the hormone calcitonin, is a sensitive marker for sepsis in human medicine, which is used for diagnosis of bacterial pneumonia in adults and neonates to initiate antibiotic therapy. Objectives: In this study, procalcitonin was evaluated as a potential biomarker for Rhodococcus equi associated pneumonia. Methods: In four foals procalcitonin was measured at four time-points (day 0 before antibiotic therapy, day 1, 3 and 5/6 during therapy) in plasma using an equine specific ELISA. Inclusion criteria for the study were a positive sepsis score, ultrasonographic evidence of pulmonary abscesses in addition >8 cm, a positive microbiology out of tracheobronchial secretion and positive response to antibiotic treatment (azithromycin 10 mg/kg BDW 24q PO and rifampicin 10 mg/kg BDW 12q PO) within a weak including improvement of clinical status and reduction of ultrasonographic score Rhodococcus equi.Background: Procalcitonin, a precursor protein of the hormone calcitonin, is a sensitive marker for sepsis in human medicine, which is used for diagnosis of bacterial pneumonia in adults and neonates to initiate antibiotic therapy. Objectives: In this study, procalcitonin was evaluated as a potential biomarker for Rhodococcus equi associated pneumonia. Methods: In four foals procalcitonin was measured at four time-points (day 0 before antibiotic therapy, day 1, 3 and 5/6 during therapy) in plasma using an equine specific ELISA. Inclusion criteria for the study were a positive sepsis score, ultrasonographic evidence of pulmonary abscesses in addition >8 cm, a positive microbiology out of tracheobronchial secretion and positive response to antibiotic treatment (azithromycin 10 mg/kg BDW 24q PO and rifampicin 10 mg/kg BDW 12q PO) within a weak including improvement of clinical status and reduction of ultrasonographic score Rhodococcus equi.

关 键 词：FOAL HORSE LUNG PNEUMONIA PROCALCITONIN Rhodococcus equi 

分 类 号：R73[医药卫生—肿瘤]