Neurological Disorders Caused by Structural Dysfunction of VANGL2  

作　　者：Liheng Shen Zixiang Xu Xiaobin Xiong Xin Sheng Liheng Shen;Zixiang Xu;Xiaobin Xiong;Xin Sheng(Department of Biochemistry, Zunyi Medical University, Zunyi, China)

机构地区：[1]Department of Biochemistry, Zunyi Medical University, Zunyi, China

出　　处：《Neuroscience & Medicine》2024年第2期106-117,共12页神经系统科学与医药（英文）

摘　　要：Background: VANGL2 plays a variety of roles in various cellular processes, including tissue morphogenesis, asymmetric cell division, and nervous system development. There is currently a lack of systematic organization in the development and disease of the nervous system. Purpose: To explore the role of VANGL2 in the development of the nervous system and related diseases. Methods: Literature review and analysis of the role of VANGL2 in the development and disease of the nervous system. Results: VANGL2 defects lead to the development of the nervous system through the misconfiguration of various cells, which affects the development of the cochlea, the conduction of neural signals, and the development of nervous system-related diseases such as Alzheimer’s disease, GBM, Bohling-Opitz syndrome, and hydrocephalus. Conclusions: The VANGL2 gene is essential for nervous system development and its deficiency is linked to severe congenital conditions and various disorders, highlighting the need for more research on treatments for related gene defects.Background: VANGL2 plays a variety of roles in various cellular processes, including tissue morphogenesis, asymmetric cell division, and nervous system development. There is currently a lack of systematic organization in the development and disease of the nervous system. Purpose: To explore the role of VANGL2 in the development of the nervous system and related diseases. Methods: Literature review and analysis of the role of VANGL2 in the development and disease of the nervous system. Results: VANGL2 defects lead to the development of the nervous system through the misconfiguration of various cells, which affects the development of the cochlea, the conduction of neural signals, and the development of nervous system-related diseases such as Alzheimer’s disease, GBM, Bohling-Opitz syndrome, and hydrocephalus. Conclusions: The VANGL2 gene is essential for nervous system development and its deficiency is linked to severe congenital conditions and various disorders, highlighting the need for more research on treatments for related gene defects.

关 键 词：VANGL2 Neurological Disorders Planar Cell Polarity (PCP) Pathway Neural Tube Defects 

分 类 号：R73[医药卫生—肿瘤]