The Impact of Migration on the Risk of Developing Multiple Sclerosis: A Literature Review from 1962 to 2022  

作　　者：Chermine Mboumba Mboumba Grass Mambila Matsalou Pupchen Gnigone Laurent Magy Aurélie Ruet Jennifer Nyangui Mapaga Michel-Arnaud Saphou-Damon Nelly Diouf Mbourou Annick Nsounda Ibrahima Camara Philomène Kouna Ndouongo Chermine Mboumba Mboumba;Grass Mambila Matsalou;Pupchen Gnigone;Laurent Magy;Aurélie Ruet;Jennifer Nyangui Mapaga;Michel-Arnaud Saphou-Damon;Nelly Diouf Mbourou;Annick Nsounda;Ibrahima Camara;Philomène Kouna Ndouongo(Department of Neurology, University Hospital of Libreville, Libreville, Gabon;Department of Neurology, University Hospital of Limoges, Limoges, France;Department of Neurology, University Hospital of Bordeaux, Bordeaux, France)

机构地区：[1]Department of Neurology, University Hospital of Libreville, Libreville, Gabon [2]Department of Neurology, University Hospital of Limoges, Limoges, France [3]Department of Neurology, University Hospital of Bordeaux, Bordeaux, France

出　　处：《Neuroscience & Medicine》2024年第4期149-164,共16页神经系统科学与医药(英文)

摘　　要：Introduction: Multiple sclerosis is a multifactorial disease, with many factors still unknown to this day. Studies on migrants play a significant role in the epidemiological and etiological research of this condition. Objective: This paper aims to study the impact of migration on the risk of developing multiple sclerosis. Methodology: A narrative review of the literature based on 80 articles retrieved from PubMed, Web of Science, Google Scholar, and ScienceDirect databases, using the following keywords: “multiple sclerosis”, “migration”, “migrants,” and “immigrants”, published from 1962 to 2022. Results: This review suggests that migration is a risk factor for multiple sclerosis. It supports the existence of an “age at migration” effect and highlights the particular role of environmental factors. The trend also points to an increased risk for second-generation immigrants compared to initial studies. Conclusion: Concepts regarding migrants and the risk of developing multiple sclerosis have evolved significantly over the past three decades. The older theory that those migrating after age 15 retain the risk of their country of birth is now less widely accepted, especially in cases of migration to high-prevalence regions, as they may influence future disease risk even into adulthood.Introduction: Multiple sclerosis is a multifactorial disease, with many factors still unknown to this day. Studies on migrants play a significant role in the epidemiological and etiological research of this condition. Objective: This paper aims to study the impact of migration on the risk of developing multiple sclerosis. Methodology: A narrative review of the literature based on 80 articles retrieved from PubMed, Web of Science, Google Scholar, and ScienceDirect databases, using the following keywords: “multiple sclerosis”, “migration”, “migrants,” and “immigrants”, published from 1962 to 2022. Results: This review suggests that migration is a risk factor for multiple sclerosis. It supports the existence of an “age at migration” effect and highlights the particular role of environmental factors. The trend also points to an increased risk for second-generation immigrants compared to initial studies. Conclusion: Concepts regarding migrants and the risk of developing multiple sclerosis have evolved significantly over the past three decades. The older theory that those migrating after age 15 retain the risk of their country of birth is now less widely accepted, especially in cases of migration to high-prevalence regions, as they may influence future disease risk even into adulthood.

关 键 词：Multiple Sclerosis MIGRATION MIGRANTS 

分 类 号：R73[医药卫生—肿瘤]