Chronic Lymphocytic Leukemia of del 17p in a Young Subject: About a Case and Reviewed a Literature  

作　　者：Amadou Djibrilla-Almoustapha Moustapha Mamane-Brah Moustapha Elhadj-Chefou Maman Rabiou Badé Faiza Abba-Ousmane Fanta Ousseini Oumoulkairou Abdoulaye-Soumana Badé Malam-Abdou Amadou Djibrilla-Almoustapha;Moustapha Mamane-Brah;Moustapha Elhadj-Chefou;Maman Rabiou Badé;Faiza Abba-Ousmane;Fanta Ousseini;Oumoulkairou Abdoulaye-Soumana;Badé Malam-Abdou(Departement of Onco-Hematology of the National Hospital of Niamey, Niamey, Niger;Faculty of Health Science, Abdou Moumouni University of Niamey, Niamey, Niger;Faculty of Health Science, André Salifou University of Zinder, Zinder, Niger;Faculty of Health Science of Maradi, Maradi, Niger)

机构地区：[1]Departement of Onco-Hematology of the National Hospital of Niamey, Niamey, Niger [2]Faculty of Health Science, Abdou Moumouni University of Niamey, Niamey, Niger [3]Faculty of Health Science, André Salifou University of Zinder, Zinder, Niger [4]Faculty of Health Science of Maradi, Maradi, Niger

出　　处：《Open Journal of Blood Diseases》2022年第4期103-109,共7页血液病期刊（英文）

摘　　要：Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation;the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient’s prognosis.Objective: To report a case of Chronic Lymphoid Leukemia in a 28-year-old young subject, with variable clinical features and a TP53 mutation, diagnosed and followed up in the Onco-Hematology department of the HNN. Observation: 28-year-old patient, having consulted for polyadenopathy and physical asthenia, whose clinical examination found a conscious patient, submaxillary, laterocervical, axillary and inguinal lymphadenopathy, bilateral, symmetrical, painless and non-compressive whose largest measures 3 cm in diameter. Hepato-splenomegaly and epistaxis. Predominantly lymphocyte hyperleukocytosis, immunophenotyping revealed low CD19+, CD5+, CD23+, CD20 monoclonal B lymphoid proliferation. The Matutes score was 4. A karyotype showed a three-chromosome translocation;the short arm of a chromosome 2, the long arm of a chromosome 11 and the long arm of a chromosome 13, and a translocation between the long arm of a chromosome 6 and the long arm of a chromosome 18. A FISH objectified a led 17p. The diagnosis of Binet Stage C CLL with positive del 17p and complex karyotype was retained. Despite the poor prognosis, the R-C (Rituximab-Chlorambucil) protocol was instituted with once-weekly transfusions. The patient is still alive in partial clinical and biological remission. Conclusion: Despite therapeutic progress, the presence of the deletion of chromosome 17p with TP53 mutation and the young age of the patient does not change the patient’s prognosis.

关 键 词：Chronic Lymphocytic Leukemia Young Subject del 17 p HNN NIGER 

分 类 号：R73[医药卫生—肿瘤]