Macrophage Activation Syndrome in a Context of Pre-B Type Lymphoblastic Acute Leucemia: A Case Report  

作　　者：Mamadou Wagué Gueye Sokhna Moumi Mbacké Daffé Mor Ngom Maguette Ndoye Papa Silman Diawara Nata Dieng Demba Makalou Macoura Gadji Macoura Gadji Awa Oumar Touré/Fall Bécaye Fall Mamadou Wagué Gueye;Sokhna Moumi Mbacké Daffé;Mor Ngom;Maguette Ndoye;Papa Silman Diawara;Nata Dieng;Demba Makalou;Macoura Gadji;Macoura Gadji;Awa Oumar Touré/Fall;Bécaye Fall(Laboratory Federation, Hô,pital Principal de Dakar (HPD), Dakar, Senegal;Onco-Hematology, Hô,pital Principal de Dakar (HPD), Dakar, Senegal;Laboratory, CHR Saint-Louis, Saint Louis, Senegal;Biological Hematology and Oncological Hematology Department (BOHD), Centre National de Transfusion Sanguine (CNTS)/FMPOS-UCAD, Dakar, Senegal;Biology, Hô,pital Aristide Le Dantec (HALD), Dakar, Senegal)

机构地区：[1]Laboratory Federation, Hô,pital Principal de Dakar (HPD), Dakar, Senegal [2]Onco-Hematology, Hô,pital Principal de Dakar (HPD), Dakar, Senegal [3]Laboratory, CHR Saint-Louis, Saint Louis, Senegal [4]Biological Hematology and Oncological Hematology Department (BOHD), Centre National de Transfusion Sanguine (CNTS)/FMPOS-UCAD, Dakar, Senegal [5]Biology, Hô,pital Aristide Le Dantec (HALD), Dakar, Senegal

出　　处：《Open Journal of Blood Diseases》2023年第4期141-147,共7页血液病期刊（英文）

摘　　要：Macrophage activation syndrome (MAS) is linked to inappropriate stimulation of macrophage cells in the bone marrow and lymphoid system, resulting in abnormal phagocytosis of figurative blood elements and the release of pro-inflammatory cytokines. It is a rare and serious hyper-inflammatory condition of diagnostic and therapeutic emergency. MAS is characterized by non-specific clinical and laboratory signs associated with images of hemophagocytosis. MAS is either “primary” (familial or pediatric forms), or “secondary/reactive” to infection, neoplasia, or autoimmune disease. Hemopathies dominate MAS secondary to neoplasia. B-type acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the proliferation and accumulation of B lymphoid progenitors, blocked at an early stage of differentiation, leading to suppression of polyclonal hematopoiesis and subsequent development of signs associated with bone marrow failure. In this context, we report the observation of a macrophage activation syndrome (MAS) associated with ALL, diagnosed at Hôpital Principal de Dakar/Senegal, in a 69-year-old patient with a well-controlled type 2 diabetes under oral antidiabetic therapy (OAD) and good general condition.Macrophage activation syndrome (MAS) is linked to inappropriate stimulation of macrophage cells in the bone marrow and lymphoid system, resulting in abnormal phagocytosis of figurative blood elements and the release of pro-inflammatory cytokines. It is a rare and serious hyper-inflammatory condition of diagnostic and therapeutic emergency. MAS is characterized by non-specific clinical and laboratory signs associated with images of hemophagocytosis. MAS is either “primary” (familial or pediatric forms), or “secondary/reactive” to infection, neoplasia, or autoimmune disease. Hemopathies dominate MAS secondary to neoplasia. B-type acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by the proliferation and accumulation of B lymphoid progenitors, blocked at an early stage of differentiation, leading to suppression of polyclonal hematopoiesis and subsequent development of signs associated with bone marrow failure. In this context, we report the observation of a macrophage activation syndrome (MAS) associated with ALL, diagnosed at Hôpital Principal de Dakar/Senegal, in a 69-year-old patient with a well-controlled type 2 diabetes under oral antidiabetic therapy (OAD) and good general condition.

关 键 词：Macrophage Activation Syndrome Acute Lymphoblastic Leukemia ADULT 

分 类 号：R73[医药卫生—肿瘤]