Can the Glucose Central Control System Dysfunctions Induce Diabetes Mellitus?  

作　　者：Altair S. de Assis João Luiz P. da Nobrega Altair S. de Assis;João Luiz P. da Nobrega(Cooperation Center for the Development of Children and Adolescents—CCDIA, Niterói, RJ, Brasil)

机构地区：[1]Cooperation Center for the Development of Children and Adolescents—CCDIA, Niterói, RJ, Brasil

出　　处：《Open Journal of Endocrine and Metabolic Diseases》2023年第12期244-255,共12页内分泌与新陈代谢疾病期刊（英文）

摘　　要：We study afresh how the glucose control system anomalies impact the organicity of the glucose homeostasis and build up events of persistent hyperglycemia and diabetes mellitus. We have used critically the state of art literature related to the subject, in order to cross, to compare, and to organize the relevant contents to create a logical and consistent support to the finds. We show that it is consistent to assume that persistent hyperglycemia and diabetes mellitus can have precursors not only in pancreas, but also in brain, mainly induced by noxious dysfunctions of hypothalamus sensor neurons circuits and external noxious elements, causing pancreas overload, and the consequent exhaustion—overburden.We study afresh how the glucose control system anomalies impact the organicity of the glucose homeostasis and build up events of persistent hyperglycemia and diabetes mellitus. We have used critically the state of art literature related to the subject, in order to cross, to compare, and to organize the relevant contents to create a logical and consistent support to the finds. We show that it is consistent to assume that persistent hyperglycemia and diabetes mellitus can have precursors not only in pancreas, but also in brain, mainly induced by noxious dysfunctions of hypothalamus sensor neurons circuits and external noxious elements, causing pancreas overload, and the consequent exhaustion—overburden.

关 键 词：Brain HYPOTHALAMUS CNS—Central Nervous System Sensor Neuron Circuits Glucose Central Control System External Noxious Elements Juvenile Persistent Hyperglycemia Diabetes Mellitus Homeostasis Euglycemia 

分 类 号：R58[医药卫生—内分泌]